Results 81 to 90 of about 12,218 (212)

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

, 2014
福岡歯科大学博士（歯学）2013年度The ciliary zonule, also known as Zinn's zonule, is composed of oxytalan fibers. However, the mechanism by which epithelial cells in the ciliary body form these fibers in not fully understood.
Oka, Kyoko, Tsuruga, Eichi, Sawa, Yoshihiko, Yamanouchi, Kaori, Ishikawa, Hiroyuki   +4 more
core   +1 more source

Structural and compositional diversity of fibrillin microfibrils in human tissues [PDF]

, 2018
Elastic fibres comprising fibrillin microfibrils and elastin are present in many tissues, including the skin, lung, and arteries where they confer elasticity and resilience.
David Knight, Clair Baldock, Watson, Rachel E B, Christopher E.M. Griffiths, Pilkington, Suzanne M, Kieran T. Mellody, Suzanne Pilkington, Alexander Eckersley, O'Cualain, Ronan, Eckersley, Alexander; id_orcid, Griffiths, Christopher Em, Knight, David, Sherratt, Michael J; id_orcid, Rachel E.B. Watson, Ronan O’Cualain, Michael J. Sherratt, Mellody, Kieran T, Baldock, Clair   +17 more
core   +1 more source

Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy

Frontiers in Physiology, 2017
Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed both to the hemodynamic consequences of normally functioning and abnormal BAV
Noor M. Yassine, Jasmine T. Shahram, Simon C. Body   +2 more
doaj   +1 more source

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Expression of the fibrillin gene family in the development, differentiation and maintenance of mesenchyme cell types [PDF]

, 2015
Connective tissue initially arises from embryonic mesenchymal stem cells (MSC) that originate from the mesoderm during embryogenesis and are capable of differentiating into connective tissue lineages such as adipocytes, osteoblasts, chondrocytes and ...
Davis, Margaret Rose
core  

Fibrillin degradation by matrix metalloproteinases: Implications for connective tissue remodelling

, 1999
Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We have previously shown that both fibrillin molecules and assembled microfibrils are susceptible to degradation by serine ...
Kielty, Cay M., Ashworth, Jane L., Rock, Matthew J., Sherratt, Michael J.; id_orcid, Shapiro, Stephen D., Murphy, Gillian, Shuttleworth, C. Adrian   +6 more
core   +1 more source

Phosphate overload via the type III Na-dependent Pi transporter represses aortic wall elastic fiber formation

Fujita Medical Journal
Objectives: Phosphate (Pi) induces differentiation of arterial smooth muscle cells to the osteoblastic phenotype by inducing the type III Na-dependent Pi transporter Pit-1/solute carrier family member 1.
Yasumasa Yoshino, Tomoka Hasegawa, Shukei Sugita, Eisuke Tomatsu, Naoya Murao, Izumi Hiratsuka, Sahoko Sekiguchi-Ueda, Megumi Shibata, Takeo Matsumoto, Norio Amizuka, Yusuke Seino, Takeshi Takayanagi, Yoshihisa Sugimura, Atsushi Suzuki   +13 more
doaj   +1 more source

Genome-Wide Identification and Expression Analyses of the Fibrillin Family Genes Suggest Their Involvement in Photoprotection in Cucumber

Plants, 2018
Fibrillin (FBN) is a plastid lipid-associated protein found in photosynthetic organisms from cyanobacteria to plants. In this study, 10 CsaFBN genes were identified in genomic DNA sequences of cucumber (Chinese long and Gy14) through database searches ...
Inyoung Kim, Sang-Choon Lee, Eun-Ha Kim, Kihwan Song, Tae-Jin Yang, Hyun Uk Kim   +5 more
doaj   +1 more source

Proteomic fingerprints of damage in extracellular matrix assemblies

Matrix Biology Plus, 2020
In contrast to the dynamic intracellular environment, structural extracellular matrix (ECM) proteins with half-lives measured in decades, are susceptible to accumulating damage.
Alexander Eckersley, Matiss Ozols, Ronan O'Cualain, Emma-Jayne Keevill, April Foster, Suzanne Pilkington, David Knight, Christopher E.M. Griffiths, Rachel E.B. Watson, Michael J. Sherratt   +9 more
doaj   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source