Results 101 to 110 of about 12,218 (212)

P10.05 REDUCED MOLECULAR FLEXIBILITY IN THE LARGE ARTERIES OF DIABETIC RATS

Artery Research, 2009
In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. In general, pathological glycosylation of extracellular matrix proteins may play an important role in increasing stiffness in ...
R. Akhtar, N. Gardiner, J.K. Cruickshank, B. Derby, M.J. Sherratt   +4 more
doaj   +1 more source

MALICoT: A pilot cross‐sectional study analyzing the effects of power training and age on endomysium content and fiber area in the soleus muscle of adult males

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract The cross‐sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty‐three clinically healthy male participants were grouped into young (20–35 years) nonphysically active controls (n = 12), young power ...
Christoph S. Clemen, Sebastian W. Humbsch, Carolin Berwanger, Leonid Mill, Andreas Schmidt, Rolf Schröder, Jörn Rittweger   +6 more
wiley   +1 more source

Synthesis of elastic microfibrillar components fibrillin-1 and fibrillin-2 by human optic nerve head astrocytes in situ and in vitro

, 2000
The purpose of this study was to identify elastic microfibrillar components fibrillin-1 and fibrillin-2 in optic nerve heads of adult normal and glaucomatous subjects.
Pena, JDO, Mello, PAA, Hernandez, M. R.
core   +1 more source

One More Piece in the Fibrillin Puzzle

, 2009
Jensen et al. report the crystal structure of a human fibrillin-1 hybrid domain in this issue of Structure. This domain is found exclusively in the fibrillin/latent transforming growth factor-β binding protein superfamily and shares structural features ...
Reinhardt, Dieter P., Hubmacher, Dirk
core   +1 more source

P3.11 INCREASED CAROTID PLAQUE OCCURRENCE IN MEN WITH THE FIBRILLIN-1 2–3 GENOTYPE

Artery Research, 2009
Background: Fibrillin-1 is an important constituent of the vascular wall and earlier studies have indicated an effect of the fibrillin-1 2–3 genotype on blood pressure as well as aortic stiffness.
R. DeBasso, B. Hedblad, J. Carlson, G. Berglund, T. Länne   +4 more
doaj   +1 more source

Dissecting the fibrillin microfibril: structural insights into organization and function.

, 2012
Force-bearing tissues such as blood vessels, lungs, and ligaments depend on the properties of elasticity and flexibility. The 10 to 12 nm diameter fibrillin microfibrils play vital roles in maintaining the structural integrity of these highly dynamic ...
Robertson, IB, Handford, Penny A., Robertson, Ian B., Handford, Penelope, Jensen, Sacha A., Handford, PA, Jensen, SA   +6 more
core   +1 more source

Segmental Stiff Skin Syndrome: A Rare Case Report from Indonesia

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)
Background: This paper reports a segmental Stiff Skin Syndrome (SSS) case in a four-year-old girl.  SSS is a rare disease characterized by skin hardening and joint stiffness due to a mutation of the fibrillin-1 (FBN-1) gene encoding the fibrillin protein.
Hafidzah Nurmastuti, Retno Danarti, Radijanti Anggraheni, Intan Arvianty, Devi Artami Susetiati, Niken Trisnowati   +5 more
doaj   +1 more source

The Biomechanics of Fibrillin Microfibrils: Lessons from the Ciliary Zonule

Cells
Marfan syndrome is an inherited connective tissue disorder that affects the cardiovascular, musculoskeletal, and ocular systems. It is caused by pathogenic variants in the fibrillin-1 gene (FBN1).
Pooja Rathaur, Juan Rodriguez, John Kuchtey, Samuel Insignares, Wendell B. Jones, Rachel W. Kuchtey, Steven Bassnett   +6 more
doaj   +1 more source

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice.

PLoS Genetics, 2015
Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause ...
Gerhard Sengle, Valerie Carlberg, Sara F Tufa, Noe L Charbonneau, Silvia Smaldone, Eric J Carlson, Francesco Ramirez, Douglas R Keene, Lynn Y Sakai   +8 more
doaj   +1 more source

Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.

, 2005
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin.
Hodson, Nigel, Sherratt, MJ, Freeman, LJ, Kielty, Cay M., Shuttleworth, Adrian, Lomas, A, Weiss, AS, Shuttleworth, A, Lomas, Amanda, Kielty, CM, Sherratt, Michael J.; id_orcid, Hodson, N, Freeman, Lyle J., Mellody, KT, Mellody, Kieran T., Weiss, Anthony S.   +15 more
core   +1 more source