Results 121 to 130 of about 1,871 (159)

Decreased Gene Expression of Fibrillin-1 in Stress Urinary Incontinence

, 2010
Aims: Studies to show impairments in the pelvic floor extracellular matrix (ECM) associated with stress urinary incontinence (SUI) has earlier been performed, but the results are contradictory.
Ekman-Ordeberg, Gunvor, Soderberg, Marie Westergren, Bystrom, Birgitta, Hammarstrom, Margareta, Malmström, Anders   +4 more
core   +1 more source

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
doaj   +1 more source

Fibrillin-1 gene intron 56 polymorphism in Turkish children with mitral valve prolapse

, 2010
Objective: Mitral valvar prolapse is the most common anomaly of the mitral valve apparatus throughout childhood. Fibrillin is one of the structural components of the elastin-associated microfibrils found in the mitral valve.
KULA, SERDAR, Karaer, Kadri, Olgunturk, Rana, Ozdemir, Osman, TUNAOĞLU, FATMA SEDEF, PERÇİN, FERDA EMRİYE, ERGÜN, MEHMET ALİ   +6 more
core   +1 more source

Fibrillin-integrin interactions in health and disease.

, 2008
Human fibrillin-1 is the major structural protein of extracellular matrix 10-12 nm microfibrils. It has a disulfide-rich modular organization which consists primarily of cbEGF (Ca(2+)-binding epidermal growth factor-like) domains and TB (transforming ...
Mardonf, H, Iqbal, S, Jensen, S, Mardon, H, Jovanović, J, Handford, P   +5 more
core   +1 more source

Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients

, 2005
Autoantibodies against short recombinant fragments of fibrillin-1 produced in bacterial expression systems have been found in tight-skin mouse, systemic sclerosis, mixed connective tissue disease, and primary pulmonary hypertension syndrome.
Sven Krengel, Dieter P Reinhardt, Brinckmann, Jürgen, Nico Hunzelmann, Ehab El-Hallous, Reinhardt, Dieter P., Krieg, Thomas, Hunzelmann, Nico, Jürgen Brinckmann, Thomas Krieg, Krengel, Sven, El-Hallous, Ehab, Sakai, Lynn Y., Lynn Y Sakai   +13 more
core   +1 more source

Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks

, 2002
Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic digestion of tissues has been utilized to release microfibrils for study.
Ono, RN, Isogai, Z, Keene, DR, Sakai, LY, Reinhardt, DP, Aspberg, Anders,, Lund University., Aspberg, Anders   +7 more
core   +1 more source

ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular Integrity

Cells
Vascular smooth muscle cells (VSMCs) play a critical role in maintaining vascular integrity. VSMC dysfunction leads to numerous vascular diseases. Adenosine deaminases acting on RNA 1 (ADAR1), an RNA editing enzyme, has shown both RNA editing and non ...
Dunpeng Cai, Shi-You Chen
doaj   +1 more source

Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro.

Oxytalan fibers are distributed in the eye and periodontal ligaments (PDL). The ciliary zonule, known as Zinn's zonule, in the eye is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1 and fibrillin-2.
Oka, Kyoko, Kawagoe, Megumi, Tsuruga, Eichi, Sawa, Yoshihiko, Ishikawa, Hiroyuki   +4 more
core  

Microenvironmental Regulation by Fibrillin-1

Microenvironmental Regulation by Fibrillin-1
Sengle G, Tsutsui K, Keene DR, Tufa SF, Carlson EJ, Charbonneau NL, et al. (2012) Microenvironmental Regulation by Fibrillin-1. PLoS Genet 8(1): e1002425. https://doi.org/10.1371/journal.pgen.1002425 Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes.
openaire  

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.
BACKGROUND AND OBJECTIVE: Oxytalan fibers are categorized as a microfibril assembly without elastin deposition, and are unique components in the periodontal ligament (PDL). However, little is known about their formation during PDL development. To clarify the mechanisms of oxytalan fiber formation in developing PDL, we performed immunohistochemical ...
openaire