Results 81 to 90 of about 1,871 (159)

Immunohistochemical Evaluation of Conjunctival Fibrillin-1 in Marfan Syndrome [PDF]

Archives of Ophthalmology, 2006
To evaluate status of conjunctival fibrillin-1 in patients with Marfan syndrome with ectopia lentis.Frozen sections of conjunctiva from 6 patients with Marfan syndrome with ectopia lentis and from 15 age-matched control subjects were stained with mouse antihuman fibrillin-1 antibody, using an avidin biotin immunoperoxidase technique.
Anuradha, Ganesh, Charles, Smith, Wilson, Chan, Sheila, Unger, Nada, Quercia, Maurice, Godfrey, Stephen, Kraft, Raymond, Buncic, Alex, Levin   +8 more
openaire   +2 more sources

The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases

Biomolecules, 2020
Secreted a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS) proteases play crucial roles in tissue development and homeostasis.
Stylianos Z. Karoulias, Nandaraj Taye, Sarah Stanley, Dirk Hubmacher   +3 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception

Journal of Anatomy, EarlyView.
In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu, Claudia Steinacher, Alexander Glueckert, Rudolf Glueckert, Hao Li, Karin Staxäng, Anneliese Schrott‐Fischer, Hanif M. Ladak, Sumit Agrawal, Helge Rask‐Andersen   +9 more
wiley   +1 more source

Sex- and age-dependent neurovascular abnormalities linked to neuroinflammation lead to exacerbated post-ischemic brain injury in Marfan syndrome mice

Redox Biology
Fibrillin 1 gene (Fbn1) mutations cause Marfan syndrome (MFS), triggering life-threatening aortic complications and multi-organ effects. MFS is increasingly linked to neurovascular complications, amplified by aortic surgery risks.
Gemma Manich, Belén Pérez, Clara Penas, Ana Paula Dantas, Joana Coutinho, Paula Sánchez-Bernadó, Julián García-Aranda, Juan Fraile-Ramos, Núria Benseny-Cases, Beatriz Martín-Mur, Anna Esteve-Codina, Isaac Rodríguez-Rovira, Lydia Giménez-Llort, Gustavo Egea, Francesc Jiménez-Altayó   +14 more
doaj   +1 more source

A novel mutation in FBN1 gene in autosomal dominant Marfan syndrome and macular degeneration in a Chinese consanguineous family [PDF]

International Journal of Ophthalmology, 2019
AIM: To report a novel mutation in FBN1 gene in a Chinese consanguineous family with common Marfan syndrome (MFS) phenotype and an unusual bilateral macular degeneration.
Ping-Bo Ouyang, Yuan Zhao, Ying-Qian Peng, Lu-Si Zhang, Jian Cao, Yun Li   +5 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Fibrillin-1, a calcium binding protein of extracellular matrix.

, 2000
Fibrillin-1 is a large extracellular matrix glycoprotein which assembles to form 10-12 nm microfibrils in extracellular matrix. Mutations in the human fibrillin-1 gene (FBN-1) cause the connective tissue disease Marfan syndrome and related disorders ...
P.A Handford, Handford, Penelope, Handford, P.A, Handford, PA   +3 more
core   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

Low‐Dose H2O2 Priming Improves Performance Under Simulated Marine Heatwave Conditions in a Coastal Bivalve

Global Challenges, Volume 10, Issue 6, June 2026.
Low‐dose hydrogen peroxide priming shapes Manila clam responses to simulated marine heatwaves, which showed faster burrowing behavior, limited transcriptional disruption, and reduced opportunistic microbiota. A long‐term field trial confirms no detectable adverse effects, supporting redox‐based chemical priming as a feasible resilience strategy in ...
Chiara Mascitelli, Giovanna Monticelli, Alessandro Nardi, Giulia Dalla Rovere, Graziano Rilievo, Ilaria Bernardini, Nicole Macrì, Deborah Cesaroni, Valentina Tavolazzi, Gabriele Andreatta, Tomaso Patarnello, Luca Bargelloni, Luca Peruzza, Maura Benedetti, Massimo Milan   +14 more
wiley   +1 more source