Results 11 to 20 of about 7,077 (251)
Frontiers in Aging Neuroscience, 2016 Tendons among connective tissue, mainly collagen, contain also elastic fibres made of fibrillin 1, fibrillin 2 and elastin that are broadly distributed in tendons and represent 1-2% of the dried mass of the tendon.
Betti Giusti, Guglielmina Pepe
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Assembly of epithelial cell fibrillins. [PDF]
Journal of Investigative Dermatology, 2001 Fibrillins are large structural macromolecules that are components of connective tissue microfibrils. Fibrillin microfibrils have been found in association with basement membranes, where microfibrils appear to insert directly into the lamina densa. It is
B. Dzamba +6 more
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Interaction of Tropoelastin with the Amino-terminal Domains of Fibrillin-1 and Fibrillin-2 Suggests a Role for the Fibrillins in Elastic Fiber Assembly* [PDF]
Journal of Biological Chemistry, 2000 Alignment of tropoelastin molecules during the process of elastogenesis is thought to require fibrillin-containing microfibrils. In this study, we have demonstrated that amino-terminal domains of two microfibrillar proteins, fibrillin-1 and fibrillin-2 ...
Timothy M. Trask +5 more
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Fibrillins in Adult Human Ovary and Polycystic Ovary Syndrome: Is Fibrillin-3 Affected in PCOS? [PDF]
Journal of Histochemistry & Cytochemistry, 2010 Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized. This study compared and contrasted fibrillin-1, −2,
C. Jordan +3 more
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Regulation of fibrillins and modulators of TGFβ in fetal bovine and human ovaries [PDF]
Reproduction, 2016 Fibrillins 1–3 are stromal extracellular matrix proteins that play important roles in regulating TGFβ activity, which stimulates fibroblasts to proliferate and synthesize collagen.
Fine +12 more
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Fibrillin Assembly Requires Fibronectin [PDF]
Molecular Biology of the Cell, 2008 Fibrillins constitute the major backbone of multifunctional microfibrils in elastic and nonelastic extracellular matrices. Proper assembly mechanisms are central to the formation and function of these microfibrils, and their properties are often ...
Laetitia Sabatier +7 more
semanticscholar +5 more sources
Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. [PDF]
PLoS Genetics, 2015 Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause ...
Gerhard Sengle +8 more
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Biogenesis and function of fibrillin assemblies [PDF]
Cell and Tissue Research, 2009 Fibrillin-1 and fibrillin-2 are large cysteine-rich glycoproteins that serve two key physiological functions: as supporting structures that impart tissue integrity and as regulators of signaling events that instruct cell performance. The structural role of fibrillins is exerted through the temporal and hierarchical assembly of microfibrils and elastic ...
F. Ramirez, L. Sakai
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eLife, 2015 During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx ...
Melissa Kelley +11 more
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The Supramolecular Organization of Fibrillin-Rich Microfibrils [PDF]
The Journal of Cell Biology, 2001 We propose a new model for the alignment of fibrillin molecules within fibrillin microfibrils. Automated electron tomography was used to generate three-dimensional microfibril reconstructions to 18.6-Å resolution, which revealed many new organizational details of untensioned microfibrils, including heart-shaped beads from which two arms emerge, and ...
Clair Baldock +7 more
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