Results 1 to 10 of about 200,421 (187)

Ultrasonic driven resveratrol induced egg-derived amyloid-like fibrils hydrocolloids for stabilizing aqueous cyanidin-3-O-glucoside. [PDF]

Ultrason Sonochem
Han X, Zhu C, Shen Y, Ai M, Ha L.
europepmc   +2 more sources

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins

Molecules, 2022
TIR-domain-containing adapter-inducing interferon-β (TRIF) is an innate immune protein that serves as an adaptor for multiple cellular signalling outcomes in the context of infection. TRIF is activated via ligation of Toll-like receptors 3 and 4.
Max O. D. G. Baker, Nirukshan Shanmugam, Chi L. L. Pham, Sarah R. Ball, Emma Sierecki, Yann Gambin, Megan Steain, Margaret Sunde   +7 more
doaj   +1 more source

Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation

Biomolecules, 2021
Henipaviruses are BSL-4 zoonotic pathogens responsible in humans for severe encephalitis. Their V protein is a key player in the evasion of the host innate immune response.
Edoardo Salladini, Frank Gondelaud, Juliet F. Nilsson, Giulia Pesce, Christophe Bignon, Maria Grazia Murrali, Roxane Fabre, Roberta Pierattelli, Andrey V. Kajava, Branka Horvat, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
doaj   +1 more source

TRANSMISSION ELECTRON MICROSCOPY FOR THE DIRECT ANALYSIS OF FIBRIN CLOT STRUCTURE [PDF]

Biotechnologia Acta, 2023
The aim of our study was to compare the structure of clots formed as a result of thrombin-induced fibrin polymerization in the presence or absence of monoclonal fibrin-specific antibodies fragments as factors that change the clot structure.
Y.P. Kucheriavyi,, I.D. Panas
doaj   +1 more source

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy

Pharmaceutics, 2023
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release in the presynaptic terminals. Pathologies related to misfolding and
Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek   +4 more
doaj   +1 more source

Assessment of Aggregated and Exosome-Associated α-Synuclein in Brain Tissue and Cerebrospinal Fluid Using Specific Immunoassays

Diagnostics, 2023
Even though it is currently well-established that α-synuclein aggregation is closely associated with the pathological events in Parkinson’s disease (PD) and several other neurodegenerative disorders, collectively called synucleinopathies, the mechanistic
Dimitrios Anagnostou, Garifalia Sfakianaki, Katerina Melachroinou, Miltiadis Soutos, Vassilios Constantinides, Nishant Vaikath, Ioanna Tsantzali, George P. Paraskevas, Omar El Agnaf, Kostas Vekrellis, Evangelia Emmanouilidou   +10 more
doaj   +1 more source

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment

Frontiers in Neuroscience, 2023
Accumulation of TMEM106B fibrils composed of cleaved C-terminal fragments (CTF) of transmembrane protein 106B (TMEM106B) has recently been observed in the brains of elderly subjects and individuals with neurodegenerative diseases.
Ruoyi Ishikawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Hirofumi Maruyama   +4 more
doaj   +1 more source

The Effect of Enzymatic Crosslink Degradation on the Mechanics of the Anterior Cruciate Ligament: A Hybrid Multi-Domain Model

Applied Sciences, 2021
The anterior cruciate ligament’s (ACL) mechanics is an important factor governing the ligament’s integrity and, hence, the knee joint’s response. Despite many investigations in this area, the cause and effect of injuries remain unclear or unknown.
Fadi Al Khatib, Afif Gouissem, Armin Eilaghi, Malek Adouni   +3 more
doaj   +1 more source

DNAJB9 Is a Reliable Immunohistochemical Marker of Fibrillary Glomerulonephritis: Evaluation of Diagnostic Efficacy in a Large Series of Kidney Biopsies

Biomedicines, 2022
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by a challenging diagnostic workup requiring ultrastructural identification of 20 nm-thick randomly oriented fibrillar deposits.
Alessandro Gambella, Chiara Pitino, Antonella Barreca, Alberto Nocifora, Manuela Maria Giarin, Luca Bertero, Luigi Biancone, Dario Roccatello, Mauro Papotti, Paola Cassoni   +9 more
doaj   +1 more source

Phenol-Soluble Modulins Modulate Persister Cell Formation in Staphylococcus aureus

Frontiers in Microbiology, 2020
Staphylococcus aureus is a human pathogen that can cause chronic and recurrent infections and is recalcitrant to antibiotic chemotherapy. This trait is partly attributed to its ability to form persister cells, which are subpopulations of cells that are ...
Mara Baldry, Martin S. Bojer, Zahra Najarzadeh, Martin Vestergaard, Rikke Louise Meyer, Daniel Erik Otzen, Hanne Ingmer   +6 more
doaj   +1 more source