Results 31 to 40 of about 200,520 (286)

Additive Manufacturing of Prostheses Using Forest-Based Composites

Bioengineering, 2020
A custom-made prosthetic product is unique for each patient. Fossil-based thermoplastics are the dominant raw materials in both prosthetic and industrial applications; there is a general demand for reducing their use and replacing them with renewable ...
Erik Stenvall, Göran Flodberg, Henrik Pettersson, Kennet Hellberg, Liselotte Hermansson, Martin Wallin, Li Yang   +6 more
doaj   +1 more source

Proteostasis Response to Protein Misfolding in Controlled Hypertension

Cells, 2022
Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira, Dário Trindade, Marisol Gouveia, Roberta Eller-Borges, Sandra Magalhães, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Alexandra Nunes, Ana Gabriela Henriques, Fernando Ribeiro, Sandra I. Vieira   +12 more
doaj   +1 more source

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Orientation Matters: Polarization Dependent IR Spectroscopy of Collagen from Intact Tendon Down to the Single Fibril Level

Molecules, 2020
Infrared (IR) spectroscopy has been used for decades to study collagen in mammalian tissues. While many changes in the spectral profiles appear under polarized IR light, the absorption bands are naturally broad because of tissue heterogeneity.
Gorkem Bakir, Benoit E. Girouard, Richard Wiens, Stefan Mastel, Eoghan Dillon, Mustafa Kansiz, Kathleen M. Gough   +6 more
doaj   +1 more source

Tau and Membranes: Interactions That Promote Folding and Condensation

Frontiers in Cell and Developmental Biology, 2021
Tau misfolding and assembly is linked to a number of neurodegenerative diseases collectively described as tauopathies, including Alzheimer’s disease (AD) and Parkinson’s disease.
Chad A. Sallaberry, Barbie J. Voss, Jaroslaw Majewski, Jaroslaw Majewski, Jaroslaw Majewski, Jacek Biernat, Eckhard Mandelkow, Eckhard Mandelkow, Eckhard Mandelkow, Eva Y. Chi, Crystal M. Vander Zanden   +10 more
doaj   +1 more source

Reinforcement of polymeric structures with asbestos fibrils [PDF]

, 1970
Investigation determines structural potential of asbestos fibrils. Methods are developed for dispersing macrofibers of the asbestos into colloidal-sized ultimate fibrils and incorporating these fibrils in matrices without causing ...
Rader, C. A., Schwartz, A. M.
core   +1 more source

Dynamic Ly alpha jets

, 2009
The solar chromosphere and transition region are highly structured and complex regimes. A recent breakthrough has been the identification of dynamic fibrils observed in H alpha as caused by field-aligned magnetoacoustic shocks.
A. Vourlidas, De Pontieu, De Pontieu, De Pontieu, de Wijn, Hansteen, Heggland, J. Koza, Judge, Judge, Korendyke, Langangen, Langangen, Langangen, Leenaarts, Patsourakos, R. J. Rutten, Rouppe van der Voort, Sterling, Suematsu   +19 more
core   +1 more source

Uncovering the Mechanism of Aggregation of Human Transthyretin. [PDF]

, 2015
The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis.
Cascio, Duilio, Eisenberg, David S, Jiang, Lin, Johnson, Lisa M, Liang, Wilson Y, Riek, Roland, Ruchala, Piotr, Saelices, Lorena, Sawaya, Michael R, Whitelegge, Julian   +9 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein

Autophagy Reports
Emerging evidence suggests that the propagation of α-synuclein pathology underlies the progression of Parkinson’s disease and supports the hypothesis that transmission of α-synuclein aggregates contributes to dopaminergic degeneration.
Emily Birnbaum, Zhenyu Yue
doaj   +1 more source