Results 21 to 30 of about 380,325 (369)
Asymmetrical Forces Dictate the Distribution and Morphology of Platelets in Blood Clots
Cells, 2021 Primary hemostasis consists in the activation of platelets, which spread on the exposed extracellular matrix at the injured vessel surface. Secondary hemostasis, the coagulation cascade, generates a fibrin clot in which activated platelets and other ...
Tatiana A. Kovalenko +13 more
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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Science, 2021 Description Fibrin gums up the works Plasmin is an abundant plasma protease that cleaves and deactivates the clot-associated protein fibrin. Human deficiencies in plasmin and its inactive proenzyme form, plasminogen (PLG), cause severe inflammation in ...
L. M. Silva +23 more
semanticscholar +1 more source
Trakya University Journal of Natural Sciences, 2023 Peritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis, hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and ...
Ece Miser Salihoğlu +2 more
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Advances in Fibrin-Based Materials in Wound Repair: A Review
Molecules, 2022 The first bioprocess that occurs in response to wounding is the deterrence of local hemorrhage. This is accomplished by platelet aggregation and initiation of the hemostasis cascade.
Ilker S. Bayer
semanticscholar +1 more source
Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases
Frontiers in Neuroscience, 2023 Neurodegenerative diseases are prevalent and currently incurable conditions that progressively impair cognitive, behavioral, and psychiatric functions of the central or peripheral nervous system. Fibrinogen, a macromolecular glycoprotein, plays a crucial
Tingting Wen, Zhaohui Zhang
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Effects of Antiplatelet Drugs on Platelet-Dependent Coagulation Reactions
Biomolecules, 2023 Activated platelets are involved in blood coagulation by exposing phosphatidylserine (PS), which serves as a substrate for assembling coagulation complexes.
Ivan A. Muravlev +6 more
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Journal of Functional Biomaterials, 2023 A major challenge for future drug development comprises finding alternative models for drug screening. The use of animal models in research is highly controversial, with an ongoing debate on their ethical acceptability.
Bianca Bindi +4 more
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Not fibrin(ogen), but fibrinogen or fibrin [PDF]
Blood, 2015 In this issue of Blood, Prasad et al describe a mouse model with a mutation in the Aα chain of fibrinogen such that no fibrin polymer is formed in vivo, allowing for the first time the differentiation of the role of fibrinogen vs fibrin oligomer or polymer in antimicrobial host defense and in hemostasis/thrombosis.
Rustem I. Litvinov, John W. Weisel
openaire +2 more sources
Fibrin(ogen) in human disease: both friend and foe
Haematologica, 2020 Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen
Rui Vilar +3 more
semanticscholar +1 more source
Bioengineering, 2020 We previously reported that corneal fibroblasts within 3D fibrin matrices secrete, bind, and organize fibronectin into tracks that facilitate cell spreading and migration.
Miguel Miron-Mendoza +4 more
doaj +1 more source