Results 51 to 60 of about 374,474 (339)

A xenograft study of human adipose stromal cell‐based vocal fold mucosal replacement in rabbits

Laryngoscope Investigative Otolaryngology, 2022
Objectives Vocal fold (VF) scarring, manifested by increased collagen, decreased glycosaminoglycans (GAGs), and disrupted elastic fibers, remains a negative consequence of VF injury or resection.
Eric K. Tran, Yazeed Alhiyari, Kevin Juarez, Bhavani Shankara Gowda, Feng Schrader, Dipti P. Sajed, Jennifer L. Long   +6 more
doaj   +1 more source

The Deleterious Effects of Impaired Fibrinolysis on Skeletal Development Are Dependent on Fibrin(ogen), but Independent of Interlukin-6

Frontiers in Cardiovascular Medicine, 2021
Chronic diseases in growing children, such as autoimmune disorders, obesity, and cancer, are hallmarked by musculoskeletal growth disturbances and osteoporosis.
Heather A. Cole, Stephanie N. Moore-Lotridge, Stephanie N. Moore-Lotridge, Gregory D. Hawley, Richard Jacobson, Richard Jacobson, Masato Yuasa, Masato Yuasa, Leslie Gewin, Leslie Gewin, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Jeffry S. Nyman, Matthew J. Flick, Matthew J. Flick, Matthew J. Flick, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker, Jonathan G. Schoenecker   +22 more
doaj   +1 more source

Differentiation Behaviour of Adipose-Derived Stromal Cells (ASCs) Seeded on Polyurethane-Fibrin Scaffolds In Vitro and In Vivo

Biomedicines, 2021
Adipose-derived stromal cells (ASCs) are a promising cell source for tissue engineering and regenerative medicine approaches for cartilage replacement.
Katrin Radeloff, Dorothee Weiss, Rudolf Hagen, Norbert Kleinsasser, Andreas Radeloff   +4 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. [PDF]

, 2000
Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell-mediated renal injury was assessed in murine crescentic glomerulonephritis (GN).
Bernatowicz, Bohm, Bradford, Connolly, Cunningham, Erlich, Grandaliano, Holdsworth, Huang, Ishihara, Kahn, Li, Mari, Mueller, Naish, Neale, Nicholson, Nystedt, Rasmussen, Rydel, Shankar, Stone, Taylor, Taylor, Thomson, Tipping, Tipping, Tipping, Ueno, Vu, Vu, Woolkalis, Xu, Xu   +33 more
core   +3 more sources

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Nature Immunology, 2018
Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link
J. Ryu, Victoria A. Rafalski, A. Meyer‐Franke, Ryan A. Adams, S. Poda, Pamela E. Rios Coronado, L. Pedersen, Veena Menon, K. M. Baeten, Shoana L. Sikorski, C. Bedard, K. Hanspers, Sophia Bardehle, Andrew S. Mendiola, Dimitrios Davalos, Michael R. Machado, Justin P. Chan, I. Plastira, Mark A. Petersen, S. Pfaff, K. Ang, K. Hallenbeck, Catriona A. Syme, H. Hakozaki, Mark Ellisman, R. Swanson, S. Zamvil, M. Arkin, S. Zorn, Alexander R. Pico, L. Mucke, Stephen Freedman, J. Stavenhagen, R. Nelson, K. Akassoglou   +34 more
semanticscholar   +1 more source

Development and Preliminary In Vivo Study of 3D‐Printed Bioactive Glass Scaffolds with Trabecular Architecture

Advanced Engineering Materials, EarlyView.
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov, Roberta Gabrieli, Avzal Akbarov, Nigora Nigmatova, Bekhzod Khabilov, Alessandro Schiavi, Martin Schwentenwein, Enrica Verné, Francesco Baino   +8 more
wiley   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Integrating platelet and coagulation activation in fibrin clot formation

Research and Practice in Thrombosis and Haemostasis, 2018
Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus.
F. Swieringa, H. Spronk, J. Heemskerk, P. V. D. van der Meijden   +3 more
semanticscholar   +1 more source