A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen [PDF]
, 2002 The wide availability of fibrinogen estimations based on the prothrombin time (PT-Fg) has caused concern about the variability and clinical utility of fibrinogen assays.
Lowe, G.D.O. +9 more
core +9 more sources
The Conversion of Fibrinogen to Fibrin: Recombinant Fibrinogen Typifies Plasma Fibrinogen [PDF]
Blood, 1997 AbstractPlasma fibrinogen is a mixture of multiple molecular forms arising mainly through alternative mRNA processing and subsequent posttranslational modification. Recombinant fibrinogen is synthesized without alternative mRNA processing in a cultured cell system that may generate novel posttranslational modifications.
O V, Gorkun +3 more
openaire +2 more sources
Microheology of fibrin clots [PDF]
, 2012 An active particle tracking microrheology technique has been developed to study the viscoelastic properties of human fibrin and plasma clots. In order to perform microrheology measurements, a magnetic microrheometer device has been adapted and a ...
Allan, Peter
core +6 more sources
Journal of Clinical Pathology, 1965 Platelet fibrinogen has been studied in normal, thrombasthenic, and hypofibrinogenaemic subjects. It has been differentiated into adsorbed (plasma) and extractable (intraplatelet) fractions. Isotopic studies suggest that exchange does not occur between intraplatelet and plasma fibrinogen and it appears possible that the intra-platelet fraction may be ...
P A, Castaldi, J, Caen
openaire +2 more sources
Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk
Haematologica, 2020 Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analysing: i) consistency in the ...
Rhodri J. King +12 more
doaj +1 more source
The Saudi Journal of Gastroenterology, 2014 The mutation γ375Arg → Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen.
Abdulrahman Al-Hussaini +6 more
doaj +1 more source
DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development. [PDF]
PLoS ONE, 2013 The fibrinogen genes FGA, FGB and FGG show coordinated expression in hepatocytes. Understanding the underlying transcriptional regulation may elucidate how their tissue-specific expression is maintained and explain the high variability in fibrinogen ...
Silja Vorjohann +6 more
doaj +1 more source
Long-term effects of hemostatic variables on fatal coronary heart disease: 30-year results from the first prospective Northwick Park Heart Study (NPHS-I) [PDF]
, 2007 Background: The long-term associations of established risk factors for coronary heart disease (CHD), for example cholesterol, are well known, but not for the less familiar hemostatic variables.
Meade, TW, de Stavola, BL
core +5 more sources
Prognostic Impact of Pretreatment Plasma Fibrinogen in Patients with Locally Advanced Oral and Oropharyngeal Cancer. [PDF]
PLoS ONE, 2016 We aimed to determine the prognostic significance of pretreatment plasma fibrinigen in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).A cohort of 183 patients with locally advanced OOSCC receiving preoperative chemoradiotherapy was ...
Daniel Holzinger +10 more
doaj +1 more source
Fibrinogen metabolic responses to trauma
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2009 Coagulation complications are significant contributors to morbidity and mortality in trauma patients. Although the lethal triad of hypothermia, acidosis and coagulopathy has been recognized for over a decade, the underlying mechanisms related to the ...
Martini Wenjun
doaj +1 more source