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Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis.
El Otmani H+7 more
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The Preparation of Human Fibrinolysin (Plasmin)
Vox Sanguinis, 1960SummaryTo date, methods reported for purifying human profibrinolysin have given erratic yields and purities. A versatile method is described for purification which can be used with most preparations of Fraction III from human plasma. This method results in a good yield of a highly purified profibrinolysin.
H. D. Anderson+4 more
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Fibrinolysin Studies in Hemophilia
Archives of Internal Medicine, 1966THE PURPOSE of this investigation was to determine whether inappropriate fibrinolysis may be detected in the blood of patients with classical, sex-linked hemophilia (hemophilia A, factor VIII deficiency). The occurrence of spontaneous, unprovoked hemorrhage in many of these patients, without an actual change in the level of factor VIII, 1 suggested ...
Lawrence H. Beizer+3 more
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Fibrinolysin Treatment of Thromboembolism
JAMA, 1964Fibrinolysin (Thrombolysin) has been used in various dosage schedules for thromboembolic disorders, but its clinical value has not been established. In this study, a single large intravenous dose was given at onset of anticoagulant therapy to 170 patients with thrombophlebitis, pulmonary embolism, or acute myocardial infarction.
George Ross Fisher+3 more
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Influence of Fibrinolysin on Shock
JAMA, 1963THE COMMON DENOMINATOR of all types of reversible shock appears to be an inadequate perfusion of vital visceral capillaries. This is affected, but not exclusively determined, by arterial blood pressure, cardiac output and venous return to the heart, vasoconstriction or dilitation, blood volume, heart failure, and other factors.
Dale G. Johnson, Robert M. Hardaway
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USE OF FIBRINOLYSIN IN SURGICAL COMPLICATIONS
Archives of Surgery, 1952WE ARE presenting our experience with the enzymatic agent fibrinolysin in the treatment of several surgical complications. One hundred instances in which the material was used are reviewed in order to evaluate its worth. The proenzyme, profibrinolysin, occurs naturally and circulates in human and animal plasma.
R. R. Margulis, B. E. Brush
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TREATMENT OF THROMBOSIS WITH FIBRINOLYSIN (PLASMIN)
Journal of the American Medical Association, 1958The possibility of dissolving a recent thrombus by the intravenous administration of a fibrinolytic enzyme was studied in a series of patients. Fibrinolysin (plasmin) was prepared in several ways from human and bovine plasma, and preparations were obtained from other laboratories also. Altogether 114 infusions of fibrinolysin were given to 37 volunteer
Julian L. Ambrus+2 more
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Enzymatic débridement with bovine fibrinolysin
The American Journal of Surgery, 1959Abstract Bovine fibrinolysin, alone or in combination with desoxyribonuclease, appears to be of value in the enzymatic debridement of ulcerating wounds. This agent achieved more rapid and frequently more effective superficial debridement of a significant proportion of ulcerating surfaces which had failed to respond satisfactorily to other forms of ...
E.F. Wolfman+3 more
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Nature, 1959
FEARNLEY'S method for estimating fibrinolytic activity of normal blood1 is based on the fact that the clot formed by adding thrombin to blood diluted 1 : 10 with phosphate buffer will lyse on incubation. This lytic activity may be lost if the specimen is permitted to stand for hours or even minutes at room temperature.
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FEARNLEY'S method for estimating fibrinolytic activity of normal blood1 is based on the fact that the clot formed by adding thrombin to blood diluted 1 : 10 with phosphate buffer will lyse on incubation. This lytic activity may be lost if the specimen is permitted to stand for hours or even minutes at room temperature.
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