Results 41 to 50 of about 3,632 (212)
Veterinary Staphylo-Fibrinolysin.
Experimental Biology and Medicine, 1936 In an examination of 132 local strains of staphylococci† it was found that 80% of all strains originally isolated from internal human lesions are capable of liquefying human fibrin.1 Approximately 90% of all strains isolated from superficial human infections, however, and all strains isolated from veterinary lesions are non-lytic by the same in vitro ...
R. R. Madison, E. E. Dart
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Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
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British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
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Debridement of wounds with honey [PDF]
, 2009 Honey has been used as a debriding agent since ancient times. Its debriding properties have been rediscovered in more recent times, with various case reports published in the latter decades of the 20th century describing its effectiveness in cleaning up ...
Molan, Peter C.
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Studies on identification of menstrual blood stain by fibrin-plate method. II. A study on the identification of menstrual blood stain [PDF]
, 1962 The fibrinolytic activity of plasmin present in menstrual blood has been studied by means of the Fibrin-Plate Method, and utilizing the findings of such a study, the identification of menstrual blood stain in legal medicine has been conducted.
Shiraishi, Masumi
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Garadacimab for the long‐term prophylaxis of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün +5 more
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Clinical evaluation of Eustachian tube transience and function in patients with different types of increased nasal resistance [PDF]
, 2009 Background/Aim. Eustachian tube is a connection between throat and the middle ear. Inflammatory processes and malformations of nasal cavity could lead to dysfunction of the whole upper respiratory tract, this emphasizing the evaluation of the Eustachian ...
Andrić Vukašin +3 more
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The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
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Modern concepts of the platelet in health and disease [PDF]
, 1962 Thesis (M.D.)--Boston ...
Estes, J. Worth
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A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
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