Results 51 to 60 of about 361 (145)
Independence of activation of the fibrinolytic system from certain immunologic systems
, 1959 Activation of the immunologic system either in vitro or in vivo results in nearly complete consumption of complement without activation of the fibrinolytic system. However complement activity decreased upon the induction of fibrinolytic activity even in
S. N. Kolmen +2 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Effects of fibrinolytic agents and heparin on intravascular clot lysis
, 1964 Clots were prepared in glass or siliconized cannulae and inserted into jugular veins 5 cm distal to semiconstricting ligatures. Clots prepared in glass tubes propagated rapidly unless heparin was administered.
Jessica H. Lewis +2 more
core +1 more source
An immobilized naphthylamide substrate for proteinases with tryptic-like specifleity [PDF]
, 1977 An immobilized amino acid naphthylamide substrate for proteinases with tryptic-like specificity was prepared by reacting -arginine [beta]-naphthylamide with an N-hydroxysuccinimide-activated derivative of agarose. Hydrolysis of the immobilized substrate (
Higgins, Deborah L., Shafer, Jules A.
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British Journal of Pharmacology, EarlyView.As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam +6 more
wiley +1 more source
Characteristics ofGaffkya homari, the Causative Agent of the Lobster Disease Gaffkemia
, 1969 Gaffkya homari did not exhibit lipase, protease, or lecithinase exoenzyme activities. The organism was coagulase and fibrinolysin negative; only lactic acid was produced from glucose.
Diane M. Foley +2 more
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Cancer Science, EarlyView.Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang +6 more
wiley +1 more source
, 1956 The enzymatic properties of both choloroform-only activated and trypsin–chloroform activated bovine fibrinolysin (plasmin) have been studied and compared with trypsin.
Edward Ronwin
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Haemophilia, EarlyView.ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini +4 more
wiley +1 more source