Results 71 to 80 of about 361 (145)

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, Volume 117, Issue 6, Page 1552-1561, December 2026.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1289-1297, December 2026.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

The isolation, characteristic and use of fibrinolysin of the plague microbe from the recombinant strain of the colon bacillus intended for constructing the immunosuspension diagnosticum

, 1992
The objects of investigation: the recombinant strain E.coli K802 (pEK4); fibrinolysin Y.pestis; the immunosuspension bearers (latex, erythrocytes). The work is aimed at studying the properties of fibrinolysin Y.pestis from the recombinant strain-producer
Lupikova Natalia Igorevna
core  

Precision-guided, personalized intrapleural fibrinolytic therapy for empyema and complicated parapneumonic pleural effusions: The case for the fibrinolytic potential [PDF]

, 2017
Complicated pleural effusions and empyema with loculation and failed drainage are common clinical problems. In adults, intrapleural fibrinolytic therapy (IPFT) is commonly used with variable results, and therapy remains empiric.
Galina Florova, Ali Azghani, Sreerama Shetty, Richard Idell, Andrey Komissarov, Najib M. Rahman, Steven Idell, Torry Tucker, Kathy Koenig   +8 more
core   +1 more source

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1455-1463, December 2026.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

Stability of Thrombin in the Presence of Fibrinolysin.

Experimental Biology and Medicine, 1947
SummaryIt has been shown that fibrinolysin does not affect the clotting activity of thrombin, and that the thrombin preparation increased the stability of fibrinolysin under the conditions of these experiments.
openaire   +3 more sources

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, Volume 100, Issue 5, Page 964-978, November 2026.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Periapical Repair [PDF]

, 2021
Introducción: La pulpa dental responde ante estímulos bacterianos, mecánicos o químicos con una Inflamación del tipo Agudo con exudación de fluidos, edema y emigración de Leucocitos. Actúan enzimas como Colagenasa, Hialuronidasa, Fibrinolisina. Entre los
Saporitti, Mauricio Edgardo, Paleo, María Amelia Clara   +1 more
core  

Action of Fibrinolysin (Plasmin) on Proteins.

Experimental Biology and Medicine, 1954
SummaryBy the action of fibrinolysin fibrinogen is converted to products which are not coagulated by thrombin, but which are precipitated by TCA. The enzyme is much less active for fibrin and casein. The former is lysed to give a product only about 20% of which is soluble in TCA.
openaire   +2 more sources