Results 61 to 70 of about 47,940 (267)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Plasminogen receptors and fibrinolysis

, 2021
The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors.
Miles, Lindsey A., Malgorzata Wilczynska, Robert J. Parmer, Miles, Lindsey A.,, Ny, Tor, Ny, Lina, Shen, Yue, Pietrzykowska, Malgorzata, Ny, Lina,, Yue Shen, Tor Ny, Parmer, Robert J.,, Shen, Yue,, Pietrzykowska, Malgorzata,, Ny, Tor,, Lina Ny, Parmer, Robert J., Lindsey A. Miles   +17 more
core   +1 more source

Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints

Advanced Robotics Research, EarlyView.
This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito, Byeongwook Jo, Tomohiro Morita, Shota Noda, Minghao Nie, Shoji Takeuchi   +5 more
wiley   +1 more source

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

Current Drug Targets, 2019
The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate
T. Urano, Yuko Suzuki, T. Iwaki, H. Sano, N. Honkura, F. Castellino   +5 more
semanticscholar   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Utility of fibrinolysis enhanced viscoelastic assays to evaluate fibrinolysis disorders in critically ill adults with severe infection: a scoping review

Annals of Intensive Care
Background: Acutely infected critically ill patients develop coagulopathies and perturbations to the fibrinolysis system that manifest as immunothrombosis.
Matthew Self, Lucy A. Coupland, Anders Aneman   +2 more
doaj   +1 more source

7.5% NaCl Resuscitation Leads to Abnormal Clot Fibrinolysis after Severe Hemorrhagic Shock and its Correction with 7.5% NaCl Adenosine, Lidocaine, and Mg2+

Journal of Emergencies, Trauma and Shock, 2018
Background: Hyperfibrinolysis is a common complication of hemorrhagic shock. Our aim was to examine the effect of small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ (ALM) on fibrinolysis in the rat model of hemorrhagic shock.
Hayley Louise Letson, Geoffrey Phillip Dobson   +1 more
doaj   +1 more source

Adrenaline May Contribute to Prothrombotic Condition via Augmentation of Platelet Procoagulant Response, Enhancement of Fibrin Formation, and Attenuation of Fibrinolysis

Frontiers in Physiology, 2021
Background: Adrenaline is believed to play a role in thrombosis and hemostasis. The complex effect of its clinically relevant concentrations on thrombus formation, coagulation and fibrinolysis in human blood has never been specifically studied.Methods ...
Agata Golaszewska, Tomasz Misztal, Natalia Marcinczyk, Ewa Chabielska, Tomasz Rusak   +4 more
doaj   +1 more source

Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays

Journal of Trauma and Acute Care Surgery, 2019
INTRODUCTION Fibrinolysis was initially defined using rapid thrombelastography (rTEG). The cutoffs for the pathologic extremes of the fibrinolytic system, hyperfibrinolysis and shutdown, were both defined based on association with mortality.
Gregory R Stettler, E. Moore, H. Moore, Geoffrey R. Nunns, C. Silliman, A. Banerjee, A. Sauaia   +6 more
semanticscholar   +1 more source

Comparative Fibrinolysis [PDF]

, 2014
In this chapter we summarize the actual knowledge about fibrinolytic assays among different animal species and we compare these findings with healthy adult human beings.Fil: Casanave, Emma Beatriz.
Juan Tentoni, Casanave, Emma Beatriz, Tentoni, Juan, Emma Beatriz Casanave   +3 more
core   +1 more source