Results 81 to 90 of about 123,453 (307)

Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates [PDF]

, 2002
Antithrombin (AT) circulates in plasma in two isoforms, AT-alpha (90-95%) and AT-beta (5-10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26 posttraumatic or postoperative septic patients, as well as in 4 ...
Donges, R., Hoffmann, J. N., Inthorn, D., Jochum, M., Muhlbayer, D., Romisch, J., Stauss, H.   +6 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. [PDF]

, 2019
BACKGROUND:Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Azmoon, Pardis, Banki, Michael A, Gonias, Steven L, Kounnas, Maria Z, Mantuano, Elisabetta, Marchese, Cinzia, Pontecorvi, Paola, Zalfa, Cristina, Zampieri, Carlotta   +8 more
core   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]

, 2002
The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Beer, N., Dodt, J., Etscheid, M., Fink, E., Seitz, R.   +4 more
core   +1 more source

Animal models of chronic thromboembolic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu, Lin‐Chao Zhou, Xiao‐Xue Zhang, Xiao‐Yang Ren, Yi Yan, Shao‐Fei Liu   +5 more
wiley   +1 more source

A novel simultaneous clot‐fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders

British Journal of Haematology, 2019
Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the ...
K. Nogami, Tomoko Matsumoto, Kana Sasai, K. Ogiwara, Nobuo Arai, M. Shima   +5 more
semanticscholar   +1 more source

Partial purification and properties of plasmonigen fractionated from horse serum and activated via staphylokinase [PDF]

, 1951
Thesis (M.A.)--Boston ...
Kaplan, Carl
core   +1 more source

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression [PDF]

, 2016
BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon ...
A Bharthuar, A Delluc, A Falanga, A Rank, A Rank, AA Khorana, AA Khorana, Anthony Maraveyas, AS Wolberg, BA Lwaleed, C Ettelaie, C Ettelaie, C Hernández, C Sapet, Camille Ettelaie, E Camerer, E Campello, E Cocco, ES Breimo, F Doormaal van, F Langer, GW Tormoen, H Kothari, I Pabinger, J Ahamed, J Thaler, J Thaler, J Thaler, JA Bastarache, JE Geddings, JH Morrissey, John Greenman, K Haubold, KG Livak, L Hu, LV Rao, M Davila, Mary EW Collier, ME Collier, ME Collier, ME Collier, ME Collier, ME Tesselaar, ML Rand, N Satta, N Tavoosi, Naima E. Benelhaj, NS Key, P Bucciarelli, R Flaumenhaft, RI Kushak, S Butenas, SJ Compton, SK Dasgupta, Sophie Featherby, T Kawamoto, V Combes, W Ruf   +57 more
core   +2 more sources

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source