Results 101 to 110 of about 47,940 (267)
Andrology, EarlyView.ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang +4 more
wiley +1 more source
Is “Physiological Lysis” in Viscoelastometry a Plasmin-Mediated Process?
DiagnosticsViscoelastic testing (VET) is widely used to guide hemostatic therapy in patients with coagulopathy. One important application is the detection of fibrinolysis, defined as a reduction in clot amplitude after maximum clot firmness (MCF), quantified as ...
Anikó Smudla +4 more
doaj +1 more source
Hemorrhagic disorders of fibrinolysis: a clinical review
Journal of Thrombosis and Haemostasis, 2018 Hyperfibrinolytic bleeding can be caused by a deficiency of one of the inhibitors of fibrinolysis (plasminogen activator inhibitor type 1 [PAI‐1] or α2‐antiplasmin [α2‐AP]), or an excess of one of the activators of fibrinolysis: tissue‐type plasminogen ...
J. Saes +3 more
semanticscholar +1 more source
Studies on Intrinsic Fibrinolysis: Activation and Inhibition
, 1992 P(論文)The activation of coagulation Facor XII results in initiation of the intrinsic fibrinolysis. This study was carried out to clarify what promoting and inhibitory factors are related to the process.
23197, 佐藤, 雅寛男
core
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
, 1984 P(論文)Mammalian blood contains two opposite enzymatic systems. One is the coagulation system capable of clot formation of blood and the other is the fibrinolytic system capable of dissolving blood clots.
安河内, 太郎, 21756
core
Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases
British Journal of Pharmacology, EarlyView.Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden +3 more
wiley +1 more source
Prediabetes, Malignant Ventricular Hypertrophy and Stroke: The SPRINT Trial
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Prediabetes and left ventricular hypertrophy (LVH) are common risk factors in adults with hypertension. Whether their coexistence, particularly in the presence of subclinical myocardial injury or stress (malignant LVH), confers a heightened stroke risk is unknown.
Arnaud D. Kaze +7 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio +38 more
wiley +1 more source
Internal fibrinolysis of fibrin clots is driven by pore expansion
Scientific ReportsBlood clots, which are composed of blood cells and a stabilizing mesh of fibrin fibers, are critical in cessation of bleeding following injury. However, their action is transient and after performing their physiological function they must be resolved ...
Rebecca A. Risman +5 more
doaj +1 more source