Results 111 to 120 of about 123,453 (307)

Internal fibrinolysis of fibrin clots is driven by pore expansion

Scientific Reports
Blood clots, which are composed of blood cells and a stabilizing mesh of fibrin fibers, are critical in cessation of bleeding following injury. However, their action is transient and after performing their physiological function they must be resolved ...
Rebecca A. Risman, Bradley Paynter, Victoria Percoco, Mitali Shroff, Brittany E. Bannish, Valerie Tutwiler   +5 more
doaj   +1 more source

Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

Allergy, Asthma & Clinical Immunology, 2018
Background Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in ...
R. Grzanka, A. Damasiewicz-Bodzek, A. Kasperska-Zajac   +2 more
doaj   +1 more source

Fibrinolysis: from blood to the brain

Journal of Thrombosis and Haemostasis, 2017
We all know about classical fibrinolysis, how plasminogen activation by either tissue‐type plasminogen activator (t‐PA) or urokinase‐type plasminogen activator (u‐PA) promotes fibrin breakdown, and how this process was harnessed for the therapeutic ...
R. Medcalf
semanticscholar   +1 more source

Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review summarizes clinical outcomes of estetrol‐containing combined oral contraceptives, showing reliable contraceptive efficacy, predictable bleeding patterns, improved well‐being, and a favorable hemostatic and metabolic profile, suggesting a promising and potentially safer alternative to ethinylestradiol‐based formulations.
Mathilde Råberg, Ingeborg Rose Vad, Kara Hildur Axelsdóttir, Ellen Christine Leth Løkkegaard   +3 more
wiley   +1 more source

Comparison of results obtained using clot-fibrinolysis waveform analysis and global fibrinolysis capacity assay with rotational thromboelastography

Scientific Reports
Global fibrinolysis assays detect the fibrinolysis time of clot dissolution using tissue-type plasminogen activator (tPA). Two such assays, clot-fibrinolysis waveform analysis (CFWA) and global fibrinolysis capacity (GFC) assay, were recently developed ...
Takumi Tsuchida, Mineji Hayakawa, Osamu Kumano   +2 more
doaj   +1 more source

Clinical and laboratory practice for lupus anticoagulant testing : an International Society of Thrombosis and Haemostasis Scientific and Standardization Committee survey [PDF]

, 2019
Background Current guidelines have contributed to more uniformity in the performance and interpretation of lupus anticoagulant (LA) testing. However, points to reconsider include testing for LA in patients on anticoagulation, cut-off values, and ...
Cohen, Hannah, Devreese, Katrien, Mackie, Ian J., the International Society for Thrombosis and Haemostasis Scientific and Standardization Committee for Lupus Anticoagulant/Antiphospholipid Antibodies, [missing]   +3 more
core   +2 more sources

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Concomitant usage of thrombolytic therapy and therapeutic hypothermia in a case of sudden cardiac arrest due to massive pulmonary embolism

Türk Kardiyoloji Derneği Arşivi, 2019
Massive pulmonary embolism is a well-known cause of sudden cardiac arrest in the adult population. Systemic fibrinolysis can be a life-saving option. Therapeutic hypothermia is highly recommended for nontraumatic sudden cardiac arrest victims to minimize
Ali Çoner, Tayfun Birtay
doaj   +1 more source

Molecular and Physical Mechanisms of Fibrinolysis and Thrombolysis from Mathematical Modeling and Experiments

Scientific Reports, 2017
Despite the common use of thrombolytic drugs, especially in stroke treatment, there are many conflicting studies on factors affecting fibrinolysis. Because of the complexity of the fibrinolytic system, mathematical models closely tied with experiments ...
Brittany E. Bannish, I. Chernysh, J. Keener, A. Fogelson, J. Weisel   +4 more
semanticscholar   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source