Results 131 to 140 of about 62,276 (286)

Thrombin-activatable fibrinolysis inhibitor

, 2004
The coagulation system is a potent mechanism that prevents blood loss after vascular injury. It consists of a number of linked enzymatic reactions resulting in thrombin generation. Thrombin converts soluble fibrinogen into a fibrin clot.
Marx, Pauline F.
core   +1 more source

Endoscopic Thrombin Injection for Gastric Variceal Bleeding: A Systematic Review and Meta‐Analysis of Observational and Trial Data

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objective The safety of endoscopic thrombin injection (ETI) for treating the bleeding of gastric varix (GV) in patients with portal hypertension requires further evaluation. This meta‐analysis systematically reviews the available evidence on the efficacy and safety of ETI for GV bleeding.
Wen Xu, Da‐qin Zhan, Ruo‐lan Wang, Shu Jin, Hui‐guo Ding   +4 more
wiley   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Lung‐Cardiovascular Interactions and Derangements in ARDS

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay   +4 more
wiley   +1 more source

Ovarian cancer during pregnancy: Pregnancy‐adjusted inflammatory and haematologic signatures for earlier risk recognition and clinical decision‐making

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Pregnancy alters haematologic and inflammatory profiles, potentially masking ovarian cancer. Integrating trimester‐specific NLR, PLR, SII, CRP, CA‐125, haemoglobin, platelet dynamics, and imaging may improve risk stratification. Multimodal biomarkers, longitudinal monitoring, and multidisciplinary assessment can support earlier detection and ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

From the lethal triad to the lethal diamond and beyond: An AI‐augmented perspective on modern hemostatic resuscitation

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background Uncontrolled hemorrhage remains the leading cause of preventable mortality in both civilian and military trauma sectors. The paradigm of resuscitation has decisively shifted from aggressive crystalloid administration to Damage Control Resuscitation, centering on early hemostatic control and the mitigation of the “Lethal Diamond ...
Jonghee Han, Junepill Seok, Su Young Yoon, Jin‐Uk Choi, Jin Suk Lee, Younghoon Sul   +5 more
wiley   +1 more source

The Effect of N‐Acetyl Cysteine on Serum Lipid Profile and Heavy Metals in Women With Endometriosis Undergoing ICSI: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Endometriosis is associated with oxidative stress and heavy metal accumulation. This study evaluated whether N‐acetylcysteine (NAC) reduces serum heavy metals and improves lipid profiles in women with endometriosis undergoing fertility treatment.
Fatemeh Khorasani, Parvaneh Mirabi, Sedighe Esmaeilzadeh   +2 more
wiley   +1 more source

Prehospital Transfusion With Red Blood Cells and Fresh Plasma in Helicopter Emergency Medical Services

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Prehospital administration of blood products is a growing practice. We aimed to describe clinical parameters and mortality following prehospital blood component therapy with red blood cells (RBC) and/or plasma in patients with traumatic and non‐traumatic haemorrhage.
Jesper Borg Andersen, Bjarke Risgaard, Rico Schou, Michael Dahl, Troels Martin Hansen, Pär I. Johansson, Christian Erikstrup, Jacob Steinmetz, Christian Fenger‐Eriksen   +8 more
wiley   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source