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Dissolving porcine and human microthrombi by short exposure to microdoses of alteplase in an in vitro model of microvascular obstruction. [PDF]
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Pharmacokinetics and Pharmacodynamics of Fibrinolytic Agents
2015In this chapter, the historical development, as well as, pharmacokinetics and pharmacological properties of the more frequently used fibrinolytic agents in pulmonary embolism patients, namely streptokinase, alteplase, and tenecteplase are analyzed. The historical development of the first-, second-, and third-generation fibrinolytics has been reviewed ...
H. David Rodriguez+1 more
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Development of New Fibrinolytic Agents
Current Pharmaceutical Design, 2006Since the activation of coagulation system and platelets triggers the thrombosis, the agents possessing anticoagulation or anti-platelet function have been used for the antithrombotic procession actions. However, in the physiological condition, the fibrinolytic system serves as antithrombotic, which removes the thrombus from the circulation.
Shigeru Ueshima, Osamu Matsuo
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Fibrinolytic Agents: Mechanisms of Activity and Pharmacology
Thrombosis and Haemostasis, 1995Fibrinolytic (thrombolytic) agents activate the fibrinolytic system by conversion of the inactive proenzyme, plasminogen into the active enzyme plasmin, that degrades fibrin. Agents available for clinical use are: the physiologic tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA)--either in a single chain (scu-PA ...
D. Collen, H.R. Lijnen
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Fibrinolytic agents in the treatment of intraventricular hemorrhage in adults [PDF]
This paper aims to review current literature on the treatment of acute intraventricular hemorrhage in adults with intraventricular infusion of fibrinolytic agents. A literature search on the topics of "intraventricular hemorrhage" or "intracerebral hemorrhage" with "thrombolytic therapy", "fibrinolytic therapy", "urokinase", "streptokinase", "tissue ...
Stephen J. Haines, Marc Lapointe
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Progress in Cardiovascular Diseases, 1979
W ITHOUT question, degenerative vascular disease remains the major cause of death and morbidity in the Western world. In the United Kingdom, cardiovascular disease is responsible for about 50% of all deaths in men aged 45-54 yr, and this must be compared with only 25% of deaths in this age group resulting from cancers.’ Although little direct proof ...
J. F. Davidson, Isobel D. Walker
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W ITHOUT question, degenerative vascular disease remains the major cause of death and morbidity in the Western world. In the United Kingdom, cardiovascular disease is responsible for about 50% of all deaths in men aged 45-54 yr, and this must be compared with only 25% of deaths in this age group resulting from cancers.’ Although little direct proof ...
J. F. Davidson, Isobel D. Walker
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Fibrinolytic agents for peripheral arterial occlusion.
Cochrane Database of Systematic Reviews, 2010BACKGROUND Peripheral arterial thrombolysis is used in the management of peripheral arterial ischaemia. Streptokinase was originally used but safety concerns led to a search for other agents. Urokinase and recombinant tissue plasminogen activator (rt-PA)
I. Robertson, D. Kessel, D. Berridge
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The clinical use of fibrinolytic agents
The American Journal of Surgery, 1977Two fibrinolytic drugs, streptokinase and urokinase, have undergone extensive clinical evaluation in the past fifteen years. Current evidence suggests that these agents may become the drugs of choice in the treatment of certain patients with venous thrombosis and pulmonary embolism.
John M. Porter, Scott H. Goodnight
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Fibrinolytic Agents in the Treatment of Necrobiosis Lipoidica
Angiology, 1976E. .. Rhodes
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