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Tenecteplase: A promising new fibrinolytic agent

Dimensions of Critical Care Nursing, 2001
Acute coronary syndrome can mean anything from unstable angina to acute myocardial infarction (MI) with ST-segment elevation. Tenecteplase, a new fibrinolytic agent used to treat ST-segment elevation acute MI, has some advantages over other fibrinolytic agents. This article describes tenecteplase's actions, indications, contraindications, and use.
M J, De Jong, W, Sabadie-Garretson
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Fibrinolytic Agents

2006
The fibrinolytic system plays a vital role in maintaining vital organ homeostasis. Fibrinolysis, defined as the dissolution of fibrin (the major scaffold for intravascular thrombus), is the process that regulates thrombus growth after hemostasis has been achieved, thus preserving tissue perfusion.
Richard C. Becker, Frederick A. Spencer
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Pharmacology of fibrinolytic agents

Progress in Cardiovascular Diseases, 1979
T HE appreciation of the high morbidity and mortality from thromboembolic occlusive vascular disease has given the impetus to a continuing search for drugs that might be of clinical value in its prevention and treatment. Anticoagulant therapy with heparin or the oral anticoagulants is primarily prophylactic, and while these drugs can prevent the ...
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The clinical use of fibrinolytic agents

The American Journal of Surgery, 1977
Two fibrinolytic drugs, streptokinase and urokinase, have undergone extensive clinical evaluation in the past fifteen years. Current evidence suggests that these agents may become the drugs of choice in the treatment of certain patients with venous thrombosis and pulmonary embolism.
J M, Porter, S H, Goodnight
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Tenecteplase: A fibrinolytic agent

British Journal of Cardiac Nursing, 2006
Thrombolysis is an established therapy for acute myocardial infarction in the UK. ST-elevation myocardial infarction almost always occurs owing to coronary atherosclerosis and coronary thrombosis which develops because of plaque disruption. Fibrinolytic agents act to dissolve the clot.
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Antibody-Directed Urokinase: A Specific Fibrinolytic Agent

Science, 1985
A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin.
C, Bode   +3 more
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Indirect Fibrinolytic Agents

1978
The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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ROLE OF FIBRINOLYTIC AGENTS IN THROMBOTIC DISEASES

Journal of the American Medical Association, 1960
Critical analysis of existing data demonstrates that fibrinolysin in conjunction with anticoagulant therapy decreases the morbidity in patients with thrombophlebitis. This conclusion was the result of comparison of data from hospital charts of 20 patients in a fibrinolysin-treated series and a control group of 22 patients. The comparison was made after
R V, CHAPPLE, H O, SINGHER
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