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[Non-enzymatic fibrinolytic agents].

Annales de l'anesthesiologie francaise, 1979
Non-enzyme fibrinolytic agents include pharmacological agents which are active in vivo but inactive in vitro and synthetic chemical compounds which when added to blood or plasma in vitro directly induce fibrinolysis. There are a number of drugs with a short duration of action such as adrenalin, nicotinic acid, vasopressin and histamine.
I M, Nilsson, U, Hedner
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Acyl-Enzymes As Fibrinolytic Agents

Thrombosis and Haemostasis, 1981
Plasminogen activators or plasmins specifically and reversibly acylated at the active centre have been used as delivery systems for fibrinolytic agents in vivo. Potential advantages of this approach, including enhanced efficacy, reduced toxicity and better control of lysis are discussed.
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Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

Thrombosis and Haemostasis, 1966
Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion ...
K M, Moser, M B, Frey
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[Pleural clot ablation and fibrinolytic agents].

Annales francaises d'anesthesie et de reanimation, 1985
Two patients presenting with an important intrapleural clot with cardiorespiratory repercussions were given in situ thrombolytic treatment after drainage with a suction tube had failed. The first patient was treated immediately after thoracophrenolaparotomy for hepatic surgery. Dissolution of the clot was obtained with two local injections of urokinase
J F, Brulé   +5 more
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Are We Using Fibrinolytic Agents Often Enough?

Annals of Internal Medicine, 1980
Excerpt The development and acceptance of new pharmacologic approaches to treatment are often painstakingly slow.
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Fibrinolytic Agents

Clinics in Haematology, 1981
U, Schmitz-Huebner, J, van de Loo
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Synthetic Fibrinolytic Agents Induction of Fibrinolytic Activity In Vitro

1978
Various asymmetric organic anions have been shown to possess the important capacity to enhance the endogenous fibrinolytic activity in human plasma in vitro. Their further development may well permit induction with them of the thrombolytic activity in human blood in vivo resulting in intravascular clot (thrombi, emboli) dissolution (thrombolysis) by ...
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Managing anticoagulation and fibrinolytic agents

2002
Abstract Anticoagulants and thrombolytic agents are widely used in many branches of medicine. These agents can be truly life-saving, but there is a narrow therapeutic margin and they can cause serious haemorrhagic complications.
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[Fibrinolytic agents--who benefits when?].

Therapeutische Umschau. Revue therapeutique, 1995
Thrombolytic therapy mimics and enhances physiological fibrinolysis. The following substances are presently available for clinical use: the nonphysiological thrombolytics streptokinase, the APSAC (acylated plasminogen-streptokinase activator complex), the physiological plasminogen activators urokinase and tissue plasminogen activator (t-PA).
W, Weichert, E, Seifried
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[Fibrinolytics and defibrinating agents].

Phlebologie, 1976
Therapeutic fibrinolysis represents the only logical means of curing thromboses, by assuring the destruction of the thrombus. This kind of therapy, which was introduced clincally over 10 years ago, has been used on only a limited scale because of the high risk of haemorrhage and the need for highly specialized laboratory control tests.
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