Results 71 to 80 of about 1,131,844 (424)

Receptor Specificity of the Fibroblast Growth Factor Family*

Journal of Biological Chemistry, 1996
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns.
D. Ornitz, Jingsong Xu, Jennifer S. Colvin, D. G. McEwen, C. MacArthur, F. Coulier, G. Gao, M. Goldfarb   +7 more
semanticscholar   +1 more source

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Nature Communications, 2018
The communication between tumor-derived elements and stroma in the metastatic niche has a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control metastatic niche formation are not fully understood.
T. Fang, Hongwei Lv, Guishuai Lv, Ting Li, Changzheng Wang, Qin Han, Lexing Yu, B. Su, Lin-na Guo, Shanna Huang, D. Cao, Liang Tang, Shanhua Tang, Mengchao Wu, Wen Yang, Hongyang Wang   +15 more
semanticscholar   +1 more source

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

Cancers, 2020
Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tumor progression and metastasis.
A. Sebastian, Nicholas R. Hum, Kelly A. Martin, Sean F Gilmore, I. Peran, S. Byers, E. Wheeler, M. Coleman, G. Loots   +8 more
semanticscholar   +1 more source

“There will be blood” from fibroblasts [PDF]

Cell Cycle, 2013
The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation.1 It is believed that HSCs emerge during embryog...
Ihor R. Lemischka, Carlos Filipe Pereira, Kateri A. Moore   +2 more
openaire   +3 more sources

Deciphering cancer fibroblasts [PDF]

Journal of Experimental Medicine, 2018
In this issue of JEM, Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow–derived cells that uniquely promotes breast cancer angiogenesis and tumor growth. The existence of functional heterogeneity among stromal populations motivates further fundamental and therapeutic inquiries.
Giulia Biffi, David A. Tuveson
openaire   +3 more sources

Phenotypic continuum of NFU1‐related disorders

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022
Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov, Maha S. Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M. Khalaf, Mohamed S. Abdel‐Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M. Elbendary, Garry Brown, Robert W. Taylor, Hamid Galehdari, Joseph J. Gleeson, Christopher J. Carroll, James A. Cowan, Andres Moreno‐De‐Luca, Henry Houlden, Reza Maroofian   +45 more
wiley   +1 more source

Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type

Frontiers in Genetics, 2020
Alport syndrome is a hereditary progressive chronic kidney disease caused by mutations in type IV collagen genes COL4A3/4/5. X-linked Alport syndrome (XLAS) is caused by mutations in the COL4A5 gene and is the most common form of Alport syndrome.
Cong Wang, Shenghui Liang, Shijia Xing, Ke Xu, Huijie Xiao, Haiyue Deng, Xiaoyuan Wang, Liangyi Chen, Jie Ding, Fang Wang   +9 more
doaj   +1 more source

The effects of colloidal nanotopography on initial fibroblast adhesion and morphology [PDF]

, 2006
Colloidal lithography offers a simple, inexpensive method of producing irregular nanotopographies, a pattern not easily attainable utilizing conventional serial writing processes.
Curtis, A., Wilkinson, C.D.W., Wood, M.A.   +2 more
core   +1 more source

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis.

Journal of Clinical Investigation, 2017
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes
H. Khalil, Onur Kanisicak, V. Prasad, Robert N. Correll, Xing Fu, T. Schips, Ronald J. Vagnozzi, Ruijie Liu, Thanh V. Huynh, Se-Jin Lee, J. Karch, J. Molkentin   +11 more
semanticscholar   +1 more source

Origins of Cardiac Fibroblasts [PDF]

Circulation Research, 2010
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Zeisberg, Elisabeth M., Kalluri, Raghu
openaire   +4 more sources