Results 311 to 320 of about 1,957,077 (351)

Fibroblast Activation Protein in Remodeling Tissues

Current Molecular Medicine, 2012
Tissue remodeling is critical during development and wound healing. It also characterizes a number of pathologic conditions, including chronic inflammation, fibrosis and cancer. It is well appreciated that reactive stromal cells play critical roles in these settings.
M, Jacob, L, Chang, E, Puré
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Sialyltransferase activities of aging diploid fibroblasts

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1979
Sialyltransferase activity and cell-cell adhesion rates of aging WI-38 cells were studied to determine the possible basis for a previously described decrease in membrane bound sialic acid and loss of proliferation of senescent cells. Ectosialyltransferase was demonstrated on the surface of both young and old WI-38 cells.
A C, Spataro, H B, Bosmann, M W, Myers-Robfogel   +2 more
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Extracellular Matrix and Fibroblast Activation in Lymphangioleiomyomatosis

American Journal of Respiratory Cell and Molecular Biology
Abstract Lymphangioleiomyomatosis (LAM) is a rare lung disease caused by hyperactivation of the mTORC1 (mechanistic/mammalian target of rapamycin 1) growth pathway in a subset of mesenchymal lung cells. Histopathologically, LAM lesions have been described as immature smooth muscle–like cells that are positive for the immature ...
Alexander R Mukhitov, Jilly F Evans, Tiegang Han, Owen A Ledwell, Ryan Rue, Kseniya Obraztsova, Susan M Lin, Maria C Basil, Edward Cantu, Yan Tang, Elizabeth P Henske, Vera P Krymskaya   +11 more
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Fibroblast Activation

JACC: Cardiovascular Imaging, 2022
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Epidermal Regulation of Dermal Fibroblast Activity

Plastic and Reconstructive Surgery, 1998
Although the association between delayed burn wound healing and subsequent hypertrophic scar formation is well-established, the mechanism for this relationship is unknown. Unhealed burn wounds lack an epidermis, suggesting a possible regulatory role for the epidermis in controlling dermal fibroblast matrix synthesis.
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The mechanobiology of fibroblast activation

Biophysical Journal, 2023
Yuan Hong, Xiangjun Peng, Haomin Yu, Mohammad Jafari, Delaram Shakiba, Jacob A. Sandler, Kenneth M. Pryse, Elliot L. Elson, Farid Alisafaei, Guy M. Genin   +9 more
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The Role and Application of Fibroblast Activating Protein

Current Molecular Medicine
Abstract: Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is rarely expressed in normal tissues but highly abundant in pathological diseases, including fibrosis, arthritis, and cancer. Ever since its discovery, we have deciphered its structure and biological properties and continue to investigate its roles in various ...
Xiao-Lou, Zhang, Wang, Xiao, Jian-Ping, Qian, Wan-Jun, Yang, Hao, Xu, Xing-da, Xu, Guo-Wei, Zhang   +6 more
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Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells

Bioactive Materials, 2021
Emmy Francek, Priyabrata Mukherjee
exaly  

Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis

Cellular and Molecular Gastroenterology and Hepatology, 2023
Detlef Schuppan, Misbah Aslam
exaly  

DNMT1 deregulation of SOCS3 axis drives cardiac fibroblast activation in diabetic cardiac fibrosis

Journal of Cellular Physiology, 2021
Xuan-Sheng Ding, Hui Tao
exaly