Results 301 to 310 of about 1,957,077 (351)

Temporal dynamics of fibroblast activation after acute myocardial infarction: Imaging and image-guided modulation

open access: yes
Thackeray J   +14 more
europepmc   +1 more source

Fibroblast Activation in Scleroderma

Scandinavian Journal of Rheumatology, 1984
Skin fibroblast cultures started from 6 scleroderma patients and 5 controls were compared with respect to synthesis of collagen and glycosaminoglycans. Fibroblast strains started from skin biopsy material from patients with active localized disease exhibited appreciably increased synthesis of collagen, whereas cultures from old sclerodermatous areas ...
T K, Vuorio   +3 more
openaire   +2 more sources

Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction

Journal of Molecular and Cellular Cardiology, 2015
Fibroblast activation protein α (FAP) is a membrane-bound serine protease expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after myocardial infarction (MI) and potential effects on cardiac wound healing are largely unknown.MI was induced in rats and FAP expression was analyzed at 3, 7 and 28 days post-MI by ...
Paolo Galuppo   +2 more
exaly   +3 more sources

Fibroblast activating protein promotes the proliferation, migration, and activation of fibroblasts in oral submucous fibrosis

Oral Diseases, 2023
Abstract Objectives Fibroblast activating protein (FAP) is associated with various organ fibrosis. However, the expression and molecular function of FAP in oral submucous fibrosis (OSF) is still unclear. Materials and Methods
Ming Li   +6 more
openaire   +2 more sources

Activation of fibroblasts in cancer stroma

Experimental Cell Research, 2010
Tumor microenvironment has emerged as an important target for cancer therapy. In particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of tumorigenesis. CAFs secrete a variety of soluble factors that act in a paracrine manner and thus affect not only cancer cells, but also other cell types present in the tumor stroma.
Kati, Räsänen, Antti, Vaheri
openaire   +2 more sources

Activated fibroblasts in cancer: Perspectives and challenges

Cancer Cell, 2023
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a popular research area over the past decade. As important players in many aspects of tumor biology, with functions ranging from collagen deposition to immunosuppression, CAFs have been the target of clinical and pre-clinical studies that have revealed their potential
Giuseppina, Caligiuri, David A, Tuveson
openaire   +2 more sources

Activation of fibroblast proliferation by Werner's syndrome fibroblast-conditioned medium

Journal of Dermatological Science, 1994
The effects of Werner's syndrome (WS) fibroblast-conditioned medium on cell proliferation and collagen production of normal fibroblasts were studied using four WS fibroblast strains. The conditioned medium from the WS fibroblasts brought about activation of normal fibroblast proliferation, whereas, that from late passage normal fibroblasts and ...
A, Hatamochi   +3 more
openaire   +2 more sources

Ecto-protein kinase activity of fibroblasts

Archives of Biochemistry and Biophysics, 1979
Abstract Isolated, intact dermal fibroblasts can transfer the terminal phosphate of adenosine triphosphate, [γ- 32 P]ATP, to an exogenously added macromolecule (histone). The incorporation of labeled phosphate to histone is attributed to an extracellularly directed protein kinase activity (ecto-kinase) which cannot be accounted for by soluble ...
T M, Chiang, E S, Kang, A H, Kang
openaire   +2 more sources

Hypotensive Activity of Fibroblast Growth Factor

Science, 1991
Acidic and basic fibroblast growth factors (FGFs) are members of a family of proteins that are broad-spectrum mitogens, have diverse hormone-like activities, and function in tumorigenesis. FGF's ability to raise the concentration of intracellular calcium ion suggests that FGF could induce the synthesis of endothelium-derived relaxing factor (EDRF) and ...
P, Cuevas   +5 more
openaire   +2 more sources

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