Results 281 to 290 of about 1,957,077 (351)

Fibroblast activation protein inhibitor radiotheranostics for imaging activated tumor stroma and guiding radionuclide therapy. [PDF]

Front Oncol
Wu H, Liu Z.
europepmc   +1 more source

Impaired Macrophage Lipid Handling Initiates Lung Fibrosis via Lipid-Mediated Fibroblast Activation

Elizabeth F. Redente, Isaiah Little, Marissa O’Callaghan, Lucas Dantas, Michelle E. Steel, Angela Cheng, Elinor Lee, Richard L. Watson, Kevin J. Williams, M.P. Keane, James P. Bridges, Alexandra L. McCubbrey, Thomas Q. de Aguiar Vallim, Cormac McCarthy, Elizabeth J. Tarling   +14 more
openalex   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Unraveling the roles of fibroblast activation protein‑positive cancer‑associated fibroblasts in cancer: From mechanisms to therapy (Review). [PDF]

Int J Oncol
Tao Z, Zhou Z, Wu Y, Hu J.
europepmc   +1 more source

Epoxytigliane modulation of dermal fibroblast-myofibroblast wound healing responses mediate enhanced anti-scarring properties via classical protein kinase C activation (Supplementary Data)

Ryan Moseley
openalex   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Bazedoxifene Attenuates Isoproterenol-Induced Cardiac Fibroblast Activation and Fibrotic Phenotype via Modulation of the IL-6/STAT3 Signaling Axis. [PDF]

Curr Issues Mol Biol
Chen X, Yang T, Tang X, Guo M, He L, Li Y.   +5 more
europepmc   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Context-dependent efficacy of fibroblast activation protein-targeted radionuclide therapy (FAP-TRT): the dual role of CAFs. [PDF]

Eur J Nucl Med Mol Imaging
Wu C, Kurniawan A, Li G, Ming Z, Nijkamp MW, van den Broek E, Noordzij W, Glaudemans AWJM, Antunes IF, Cornelissen B.   +9 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source