Results 271 to 280 of about 1,957,077 (351)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Near-infrared light-controlled catalytic hairpin assembly fluorescent biosensor for the sensitive and specific detection of fibroblast activation protein. [PDF]

Nanoscale Adv
Wu J, Zheng X, Huang J, Chen E.
europepmc   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction. [PDF]

Eur Respir J
Miyashita Y, Kaiho T, Nagata H, Hiroshima T, Sugiura Y, Zhang K, Kelly ME, Yan Y, Toyoda T, Steffens A, Sun H, Abdala-Valencia H, Kimura T, Wang B, Atkinson C, Bharat A, Kanou T, Shintani Y, Kurihara C.   +18 more
europepmc   +1 more source

An Ibuprofen-Eluting Electrospun Membrane Prevents Ureteral Fibrosis by Dampening Macrophage-Associated Fibroblast Activation

Xi Zhang, Da Zhong, Zihao Xu, Yi Li, Jie Zheng, Yuan Tian, Chao Qin, Renjun Pei, Jinglei Wu, Yichun Wang, Xi Zhang   +10 more
openalex   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Label-Free Monitoring of Cancer-Associated Fibroblast Activation Using NAD(P)H Fluorescence Lifetime Imaging. [PDF]

Chembiochem
Anseeuw N, Escalona-Noguero C, Vankevelaer G, Aytekin S, De Wever O, Elia I, Rocha S, Solís-Fernández G.   +7 more
europepmc   +1 more source

GRK2–JAK1 binding represses hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting STAT3 activation

Chenchen Han, Shujun Zuo, Liping Jiang, Fuyuan Guo, Haozhou Guo, Hongzheng Tan, Huazhan Sun, Weikang Wang, Jintao Gu, Gaoxin Xiong, Yang Ma, Wei Wei   +11 more
openalex   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source