Results 111 to 120 of about 5,708,174 (240)

Molecular Mechanisms of Cardiac Fibrosis: A Pathologist’s Perspective

Current Issues in Molecular Biology
Cardiac fibrosis represents a final common pathway in a wide range of cardiac disorders, leading to structural remodeling, diastolic dysfunction, and heart failure.
Andrea Marzullo, Cecilia Salzillo
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract

Urology Case Reports
Urothelial carcinomas of the upper urinary tract (UTUC) are relatively rare and challenging to treat. We present a case report of a 55-year-old male patient with high-grade renal UTUC who received adjuvant pembrolizumab immunotherapy.
L. Gallardo Zamora, F.C. von Rundstedt, C. Wach, W.P. Fendler, I. Maric, K. Herrmann, J.T. Siveke, P.F.-Y. Cheung, V. Grünwald   +8 more
doaj   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

GLUT and FAPα as molecular markers for interstitial lung disease in systemic sclerosis

Respiratory Research
Background The clinical management of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is challenging due to its heterogeneous progression.
Bo Broens, Conny J. van der Laken, Teodora Radonic, Esther J. Nossent, Xue D. Manz, Douwe J. Mulder, Yehya Al-Adwi, C. Tji Gan, Wim Timens, Alexandre E. Voskuyl, Jan Willem Duitman   +10 more
doaj   +1 more source

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells

, 1997
A phospholipase D1 (PLD1) was purified from rat brain by the use of antibody-coupled protein A Sepharose. We found that protein kinase C alpha (PKC alpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).
Hannun, YA, Hong, Seungbum, Kim, Yong, Kim, Y, Lee, TG, Lee, Sang Do, Lee, SD, Bae, Sunsik, Ryu, Sung Ho, Ryu, SH, Suh, Pann-Ghill, Obeid, LM, Suh, PG, Park, Jong Bae, Park, JB, Yi, Kye Sook, Obeid, Lina M, Kim, JH, Kim, Jae Ho, Hong, S, Yi, KS, Hannun, Yusuf A, Lee, Taehoon G., Bae, S, Seungbum Hong, Lina M Obeid, Sunsik Bae, Jong Bae Park, Kye Sook Yi, Sang Do Lee, Jae Ho Kim, Yong Kim, Yusuf A Hannun, Pann-Ghill Suh, Taehoon G Lee, Sung Ho Ryu   +35 more
core   +1 more source

Selective Laser Sintering and Graphitization for Mono‐Matrix Unibody Fabrication of Integrated Stereo‐Circuit and Stereo‐Fluidic Wearable Electronics

Advanced Materials, EarlyView.
A novel selective laser sintering and graphitization (SLSG) 3D printing technology enables unibody fabrication of compacted insulating structures and conductive circuits in fluidic‐integrated wearable electronics through adaptive photonic modulation.
Li Zhang, Wing Cheung Mak
wiley   +1 more source