Results 91 to 100 of about 5,708,174 (240)

Therapeutic Effects of Omentin-1 on Pulmonary Fibrosis by Attenuating Fibroblast Activation via AMP-Activated Protein Kinase Pathway

, 2022
Idiopathic pulmonary fibrosis (IPF) is a fatal age-related chronic lung disease, characterized by progressive scarring of the lungs by activated fibroblasts.
Haipeng Cheng, Shaojie Yue, Zhou, Yan, Xiaohong Li, Cheng, Haipeng, Yan Zhou, Yunna Zhang, Hui Xie, Li, Xiaohong, Jianping Xu, Luo, Ziqiang, Yue, Shaojie, Feng, Dandan, Ziqiang Luo, Dandan Feng, Zhang, Yunna, Xu, Jianping, Xie, Hui   +17 more
core   +1 more source

Locoregional radionuclide therapy of glioblastoma with [211At]At-PDA-FAPI

Scientific Reports
Glioblastoma is the most common and aggressive tumor of the central nervous system. Locoregional administration of therapeutic radiopharmaceuticals appears to be a promising modality for recurrent glioblastomas.
Huan Ma, Tianzhen Ye, Guofeng Qu, Yilin Qin, Jiali Liao, Yuanyou Yang, Wei Zhang, Ning Liu, Feize Li   +8 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile, Paleologou Katerina, Vitte Jérémie, Duchateau, René, Corti, Olga, Hamon Michel, Perez-Diaz, Fernando, Fournier Margot, Fernando Perez-Diaz, Saurini, Françoise, Traver, Sabine, Katerina Paleologou, Joubert, Chantal, Hilal A Lashuel, Christian Haass, Philipp J Kahle, Jean-Philippe Dullin, Charles Duyckaerts, Joubert Chantal, Garrigue Jérôme, Ardila-Osorio Héctor, Langui, Dominique, Michel Hamon, Jérémie Vitte, Margot Fournier, Cornilleau Fabien, Paleologou, Katerina, Duyckaerts Charles, Hanoun Naïma, Françoise Saurini, Corti Olga, Cécile Goujet-Zalc, Kahle Philipp J., Fabien Cornilleau, Haass Christian, Alexis Brice, Naïma Hanoun, Kahle, Philipp J., Cohen-Salmon, Charles, Dullin, Jean-Philippe, Fournier, Margot, Olga Corti, Hamon, Michel, Chantal Joubert, Vitte, Jérémie, René Duchateau, Cohen-Salmon Charles, Dominique Langui, Héctor Ardila-Osorio, Kahle, Philipp J, Traver Sabine, Cornilleau, Fabien, Lashuel Hilal A., Duchateau René, Jérôme Garrigue, Ardila-Osorio, Héctor, Langui Dominique, Garrigue, Jérôme, Haass, Christian, Lashuel, Hilal A., Brice Alexis, Duyckaerts, Charles, Brice, Alexis, Charles Cohen-Salmon, Perez-Diaz Fernando, Sabine Traver, Lashuel, Hilal A, Saurini Françoise, Goujet-Zalc, Cécile, Dullin Jean-Philippe, Hanoun, Naïma   +70 more
core   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule [PDF]

, 2003
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite.
Riley, Eleanor M, Sultan, Ali A, J. Brian de Souza, de Souza, J Brian, Eleanor M. Riley, Corran, Patrick H, Patrick H. Corran, Omer, Fakhreldin M, Riley, EM, Sultan, AA, Corran, PH, Ali A. Sultan, Omer, FM, de Souza, JB, Fakhreldin M. Omer   +14 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Fibroblast Activation Protein Inhibitor-PET Imaging in Colorectal Cancer

, 2023
Fibroblast activation protein inhibitor (FAPI)-PET imaging holds great promise for improving the clinical management of colorectal cancer. High fibroblast activation protein expression is particularly observed in lymph node metastases, in the aggressive ...
Lam, Marnix, Kranenburg, Onno, Strating, Esther, van de Loo, Anne, Elias, Sjoerd, Researchgr. Nucleaire Geneeskunde, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Cancer, Epi Kanker Team C, Lab Translational Oncology, Cancer   +10 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

TNF alpha induces HIF-1 alpha expression through activation of IKK beta [PDF]

, 2010
[[abstract]]The transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNF alpha).
Kuo, HP (Kuo, Hsu-Ping); Lee, DF (Lee, Dung-Fang); Xia, WY (Xia, Weiya); Wei, YK (Wei, Yongkun); Hung, MC (Hung, Mien-Chie)
core