Results 71 to 80 of about 5,708,174 (240)

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

, 2010
The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein-alpha ...
Lukasz Magiera, Kraman, Matthew, Fearon, Douglas T, Magiera, L., Jones, J. O., Bambrough, P. J., Jones, James O, Magiera, Lukasz, Roberts, Edward W, Douglas T. Fearon, Aarthi Gopinathan, Roberts, E. W., James O. Jones, Kraman, M., Tuveson, David A, Tuveson, D. A., Bambrough, Paul J, Paul J. Bambrough, Arnold, J. N., Matthew Kraman, Edward W. Roberts, Arnold, James N, Gopinathan, A., James N. Arnold, Fearon, D. T., David A. Tuveson, Gopinathan, Aarthi   +26 more
core   +1 more source

Expanding horizons: radiolabeled FAPI in imaging of autoimmune diseases

Frontiers in Immunology
Fibroblast activation protein alpha (FAP) is a type II transmembrane protease that exhibits both dipeptidyl peptidase and endopeptidase activities.
Jiaoniu Duan, Jinfang Gao, Gailian Zhang, Liyun Zhang   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. [PDF]

, 2020
Cytokine-primed neutrophils can undergo a nonapoptotic type of cell death using components of the necroptotic pathway, including receptor-interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase. In this report, we provide
Perozzo, Remo, Hosseini, Aref, Simon, Hans-Uwe, Kuchen, Stefan, Gessier, Francois, Amirshahrokhi, Keyvan, Loetscher, Pius, Yousefi, Shida, Lötscher, Pius, Stojkov, Darko, Wang, Xiaoliang, Kuchen S, Yousefi S, Simon HU, Gessier F, Amirshahrokhi K, Perozzo R, Lötscher P, Wang X, Hosseini A, Stojkov D   +20 more
core   +1 more source

Delayed 68Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction

International Journal of Cardiology: Heart & Vasculature
Purpose of the Report: Combined cardiac 68Ga-Fibroblast-Activation Protein-alpha inhibitor (FAPI) positron-emission tomography (PET) and cardiac magnetic resonance imaging (MRI) constitute a novel diagnostic tool in patients for the assessment of ...
Jana Kupusovic, Lukas Kessler, Sandra Kazek, Michal Kamil Chodyla, Lale Umutlu, Fadi Zarrad, Michael Nader, Wolfgang P. Fendler, Zohreh Varasteh, Ken Hermann, Dobromir Dobrev, Reza Wakili, Tienush Rassaf, Johannes Siebermair, Christoph Rischpler   +14 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein [PDF]

, 2019
The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic ...
De Matos, Raphaël, Staedler, D., Constant, Samuel, Gerber-Lemaire, S., Staedler, Davide, Gerber-Lemaire, Sandrine, De Matos, R., Mas, C., Constant, S., Gerber, Sandrine, Vuilleumier, Jérémy, Vuilleumier, J., Mas, Christophe   +12 more
core   +1 more source

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Drug Design, Development and Therapy, 2015
Lijun Zhang, Jie Zhang, Changgeng Xu, Xiangjun Zhou, Wei Wang, Renping Zheng, Wei Hu, Pin Wu Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China Abstract: Fibroblast activation and ...
Zhang LJ, Zhang J, Xu CG, Zhou XJ, Wang W, Zheng RP, Hu W, Wu P   +7 more
doaj  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source