Results 61 to 70 of about 5,708,203 (270)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation

Pharmacological Research, 2023
Pulmonary fibrosis is a progressive and fatal fibrotic lung disease with mysterious pathogenesis and limited effective therapies. G protein-coupled receptors (GPRs) participate in a variety of physiologic functions, and several GPRs have critical ...
Zhengnan Ren, Xiaohua Pan, Jiahong Li, Xiaoliang Dong, Xing Tu, Li-Long Pan, Jia Sun   +6 more
doaj   +1 more source

The Effects of Berberine and Nitroxl (HNO) on the Glucose Uptake in L929 Fibroblast Cells [PDF]

, 2012
Berberine, which has a long history of use in Chinese medicine, has recently been shown to have efficacy in the treatment of diabetes. While the hypoglycemic effect of berberine has been clearly documented in animal and cell line models, such as 3T3-L1 ...
Chenge, Jude Terver-Jeremiah
core  

Analysis of Drosophila Fibroblast Growth Factor Functional Domains [PDF]

, 2011
The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease.
Tulin, Sarah Lynn
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Evaluation of folate receptor-alpha and other surface markers as potential targets for radionuclide therapy of ovarian cancer

EJNMMI Research
Background Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecological malignancies, primarily due to frequent late-stage diagnosis and the development of resistance to chemotherapy.
Benjamin D. Hunkeler, Jakob Heimer, Ana Katrina Mapanao, Matthias Choschzick, Cristina Müller, Niels J. Rupp   +5 more
doaj   +1 more source

Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway. [PDF]

PLoS ONE, 2014
Transdifferentiation of human Tenon fibroblasts to myofibroblasts and subsequent deposition of extracellular matrix is a key step in the scarring after glaucoma filtration surgery.
Yong-Heng Luo, Ping-Bo Ouyang, Jiao Tian, Xiao-Jian Guo, Xuan-Chu Duan   +4 more
doaj   +1 more source

Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-κB pathway

Bone & Joint Research, 2021
Aims: Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), which are proinflammatory mediators and a novel biomarker of oxidative
Aiju Lou, Le Wang, Weinan Lai, DingJi Zhu, Weirong Wu, Zhao Wang, Zihong Cai, Min Yang   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MD Trajectories for "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript

, 2023
<p>Supplementary Information for the "In-Silico analysis of Fibroblast Activation Protein (FAP) ligand selectivity" Manuscript</p ...
Ciancetta, Antonella
core   +1 more source