Results 311 to 320 of about 407,104 (349)

Determination of fibroblast growth factor 23

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2009
Background Fibroblast growth factor 23 (FGF-23) is a recently discovered hormone, which plays a key role in phosphate regulation. To investigate whether FGF-23 can be determined reliably, we validated the three available FGF-23 assays. Methods Currently, two intact FGF-23 assays (Kainos; Immutopics) and one C-terminal FGF-23 assay (Immutopics) are ...
Heijboer, Annemieke C., Levitus, Marieke, Vervloet, Marc G., Lips, Paul, ter Wee, Piet M., Dijstelbloem, Hilde M., Blankenstein, Marinus A.   +6 more
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Fibroblast Growth Factor 23 and Its Receptors

Therapeutic Apheresis and Dialysis, 2005
Abstract:  Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately ...
Xijie, Yu, Kenneth E, White
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Inherited fibroblast growth factor 23 excess

Best Practice & Research Clinical Endocrinology & Metabolism
Syndromes of inherited fibroblast growth factor 23 (FGF-23) excess encompass a wide spectrum that includes X-linked hypophosphataemia (XLH), autosomal dominant and recessive forms of rickets as well as various syndromic conditions namely fibrous dysplasia/McCune Albright syndrome, osteoglophonic dysplasia, Jansen's chondrodysplasia and cutaneous ...
Kripa Elizabeth, Cherian, Thomas Vizhalil, Paul   +1 more
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Fibroblast growth factor 23 and phosphate homeostasis

Current Opinion in Nephrology and Hypertension, 2019
The current review highlights recent advances in the area of renal tubular phosphate transport and its regulation by fibroblast growth factor 23 (FGF23), a potent regulator of phosphate homeostasis.Recent studies demonstrate that FGF23 binds to both membrane and soluble form of α-klotho to activate FGF receptor signaling pathways.
Shanthi, Balani, Farzana, Perwad
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Fibroblast Growth Factor 23–Mediated Bone Disease

Endocrinology and Metabolism Clinics of North America, 2017
Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders ...
Anda R, Gonciulea, Suzanne M, Jan De Beur   +1 more
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Fibroblast growth factor 23 and the heart

Current Opinion in Nephrology and Hypertension, 2012
Elevated serum levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) are strongly associated with chronic kidney disease (CKD) progression and mortality, and are also independently associated with left ventricular hypertrophy, a major contributor to cardiovascular disease (CVD) and death in CKD patients.
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Fibroblast growth factor 23 in untreated nephrotic syndrome

Nephrology, 2018
AbstractAimDespite its importance in bone and cardiovascular disease in subjects with kidney disease, there are no data on fibroblast growth factor 23 (FGF23) perturbations in nephrotic syndrome. We evaluated FGF23 and markers of mineral bone metabolism in subjects with untreated NS.MethodsIn this cross‐sectional study, we measured circulating levels ...
Ashok Kumar, Yadav, Raja, Ramachandran, Abhinav, Aggarwal, Vinod, Kumar, Krishan Lal, Gupta, Vivekanand, Jha   +5 more
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Vitamin A regulates fibroblast growth factor 23 (FGF23)

Nutrition, 2020
Renal phosphate and vitamin D metabolism are regulated by proteohormone fibroblast growth factor 23 (FGF23), which is secreted by bone cells. FGF23 inhibits phosphate reabsorption and the production of calcitriol, active vitamin D (1,25(OH)2D3). FGF23 generated by other cells exerts further paracrine effects in the liver, heart, and immune system.
Steffen Rausch, Michelle Barholz, Michael Föller, Martina Feger   +3 more
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Phosphate wasting and fibroblast growth factor-23

Current Opinion in Endocrinology, Diabetes & Obesity, 2013
The purpose of this study is to review the regulation of phosphate and recent progress in fibroblast growth factor-23 (FGF-23), a key phosphate regulatory hormone.Phosphate is required for mineralization of bone, muscle strength and a host of biologic functions. Phosphate is sensed by bone that responds with secretion of FGF-23. The major action of FGF-
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Anti-fibroblast growth factor 23 antibody therapy

Current Opinion in Nephrology and Hypertension, 2014
The review is intended to provide an update on the expanding knowledge regarding diseases caused by the excess actions of fibroblast growth factor 23 (FGF23) and also on the new therapeutic measures for these diseases, with an emphasis on the anti-FGF23 antibody.FGF23 decreases serum phosphate and 1,25-dihydroxyvitamin D levels.
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