Results 71 to 80 of about 11,074,756 (345)
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
Kidney International, 2015 Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether inflammation and iron deficiency regulate FGF23.
Valentin David +10 more
semanticscholar +1 more source
FGFR4 (fibroblast growth factor receptor 4) [PDF]
, 2012 Review on FGFR4 (fibroblast growth factor receptor 4), with data on DNA, on the protein encoded, and where the gene is ...
Barderas, Rodrigo +5 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Fibroblast growth factors as tissue repair and regeneration therapeutics [PDF]
PeerJ, 2016 Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or ...
Quentin M. Nunes +4 more
doaj +2 more sources
Fibroblast growth factor signaling in skeletal development and disease
Genes & Development, 2015 In this review, Ornitz and Marie examine progress made on understanding the functions of the fibroblast growth factor (FGF) signaling pathway during critical stages of skeletogenesis and explore the mechanisms by which mutations in FGF signaling ...
D. Ornitz, P. Marie
semanticscholar +1 more source
FGFR2 (fibroblast growth factor receptor 2) [PDF]
, 2009 Review on FGFR2 (fibroblast growth factor receptor 2), with data on DNA, on the protein encoded, and where the gene is ...
Katoh, M
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*
Journal of Biological Chemistry, 2006 The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the
H. Kurosu +10 more
semanticscholar +1 more source
FGF2 (fibroblast growth factor 2 (basic)) [PDF]
, 2011 Review on FGF2 (fibroblast growth factor 2 (basic)), with data on DNA, on the protein encoded, and where the gene is ...
Murphy, P +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source