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The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies

Cytokine & Growth Factor Reviews, 2007
Basic fibroblast growth factor/fibroblast growth factor-2 is one of the best characterized of the pro-angiogenic cytokines. This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature.
RIBATTI D   +3 more
openaire   +3 more sources

Regeneration of the tympanic membrane using fibroblast growth factor-2.

Journal of Laryngology and Otology, 2018
OBJECTIVE A systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation. METHODS The PubMed database was searched for relevant studies.
Z. Lou, Z. Lou, J. Xiao
semanticscholar   +1 more source

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Linda Jackson-Boeters   +3 more
openaire   +3 more sources

Ca2+Oscillations induced by fibroblast growth factor 2 inXenopusoocytes expressing fibroblast growth factor receptors

Molecular Membrane Biology, 1997
Double electrode voltage clamp technique was used to follow precisely the calcium signalling pathway activated by FGF receptors from a normal and a carcinogenous cell environment. Functional FGF receptors were expressed in Xenopus oocytes following either the injection of PFR1 cRNA from Pleurodeles, an homologue of the human FGFR1 mRNA, or breast ...
Malo, Michel   +4 more
openaire   +3 more sources

Stimulation of wound healing by PU/hydrogel composites containing fibroblast growth factor-2.

Journal of materials chemistry. B, 2015
In this study, polyurethane (PU)/hydrogel composites were fabricated for wound healing applications. The hydrogel is a copolymer of thermosensitive N-isopropyl acrylamide (NIPAAm) and acrylic acid (AAc).
Yiu-Jiuan Lin   +5 more
semanticscholar   +1 more source

New insights in the biology of fibroblast growth factor-2

Angiogenesis, 1997
Fibroblast growth factor (FGF)-2 stimulates endothelial cell proliferation and is a potent angiogenic molecule in vitro and in vivo. In this review, we have focused on recent findings that relate to the mechanism of action and function of FGF-2. FGF-2 is expressed as four different isoforms: one 18 kDa FGF-2 form that is mainly cytoplasmic and three ...
Andreas Bikfalvi   +3 more
openaire   +3 more sources

The role of fibroblast growth factor 2 in drug addiction

European Journal of Neuroscience, 2018
AbstractFibroblast growth factor 2 (FGF2) is a member of the FGF‐family, which consists of 22 members, with four known FGF receptors (five in humans). Over the last 30 years, FGF2 has been extensively studied for its role in cell proliferation, differentiation, growth, survival and angiogenesis during development, as well as for its role in adult ...
Oren Even‐Chen, Segev Barak
openaire   +2 more sources

Characterization of Fibroblast Growth Factor-2 Binding to Ribosomes

Growth Factors, 1996
We have examined the binding of FGF-2 to ribosomes and have found that in NIH 3T3 cells that synthesize high amounts of all FGF-2 forms, both 18 kDa and HMW forms of FGF-2 bind to ribosomes. Ribosomes purified from these cells were treated with RNase or puromycin to identify the binding site of FGF-2 on the ribosome.
Takashi Morimoto   +2 more
openaire   +3 more sources

Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue.

Experimental Cell Research, 1999
The differentiated phenotype of chondrocytes from hyaline cartilage is gradually lost during expansion in monolayers. Chondrocytes can reexpress their differentiated phenotype by transfer into an environment that prevents cell flattening, but serially ...
Ivan Martin   +4 more
semanticscholar   +1 more source

The role of fibroblast growth factor-2 (FGF-2) in hematopoiesis

Progress in Growth Factor Research, 1995
Basic fibroblast growth factor (bFGF or FGF-2) is an angiogenic and pleiotropic growth factor involved in the proliferation and differentiation of numerous cell types. It is expressed mostly in tissues of mesoderm and neuroectoderm origin, and is thought to play an important role in the mesoderm induction.
Andreas Bikfalvi, Michèle Allouche
openaire   +3 more sources

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