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Fibroblast growth factor-2, bone homeostasis and fracture repair.

Current pharmaceutical design, 2013
There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2).
Yurong Fei, G. Gronowicz, M. Hurley
semanticscholar   +1 more source

Fibroblast growth factor‐2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor‐2

Journal of Neuroscience Research, 2011
AbstractNeurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor‐2 (FGF‐2) in adult hippocampal neurogenesis has not been firmly established.
Werner, Sandra   +2 more
openaire   +4 more sources

Uterine fibroblast growth factor-2 and embryonic fibroblast growth factor receptor-1 at the beginning of gastrulation in the rabbit

Anatomy and Embryology, 1996
Fibroblast growth factor-2 (FGF-2) induces gastrulation of rabbit blastocysts in vitro and is present in the uterine secretion at day 6 after mating. The following study was made in order to show if changes in the uterine FGF-2 concentration or in the FGF receptor concentration of the embryonic tissues point to a regulation of this event. By the use of
Christoph Kirchner, Carsten Gründker
openaire   +3 more sources

Expression of fibroblast growth factor receptor 3 by fibroblast growth factor 2 in cultured chick embryo chondrocytes

Cell Biology International, 2005
Although fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor 3 (FGFR3) both inhibit longitudinal bone growth, little is known about the relationship between FGF2 and FGFR3. Accordingly, the current study examined the expression of FGFR3 mRNA after the administration of FGF2 using cultured chondrocytes from day 17 chick embryos to ...
Jo-Young Suh   +4 more
openaire   +3 more sources

Modulation of proliferation and differentiation of human bone marrow stromal cells by fibroblast growth factor 2: potential implications for tissue engineering of tendons and ligaments.

Tissue engineering, 2005
Bone marrow stromal cells (BMSCs) play a central role in the repair and regeneration of mesenchymal tissues. For tissue engineering of ligaments and tendons, both stimulation of cell proliferation and differentiation with increased expression of ...
S. Hankemeier   +7 more
semanticscholar   +1 more source

The Unconventional Secretory Machinery of Fibroblast Growth Factor 2

Traffic, 2011
Unconventional secretory proteins represent a subpopulation of extracellular factors that are exported from eukaryotic cells by mechanisms that do not depend on the endoplasmic reticulum and the Golgi complex. Various pathways have been implicated in unconventional secretion including those involving intracellular membrane‐bound intermediates and ...
openaire   +3 more sources

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood, 2004
The long pentraxin PTX3 is a soluble pattern recognition receptor produced by monocytes and endothelial cells that plays a nonredundant role in inflammation.
M. Rusnati   +8 more
semanticscholar   +1 more source

Expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and hepatocellular carcinoma.

Digestive diseases and sciences, 1998
This study was performed to examine the immunohistochemical expression of fibroblast growth factor-1 and fibroblast growth factor-2 in normal liver and a total of 31 cases of hepatocellular carcinoma (HCC). Reactivity for both types of angiogenic factor did not exist in any cellular component of normal liver.
Nan Haw Chow   +6 more
openaire   +3 more sources

Role of Fibroblast Growth Factor-2 in Astrogliosis

2002
Astrocytes comprise the most numerous cellular element of the brain. Though once thought to merely provide structural support for neurons, astrocytes are now known to participate in many aspects of normal nervous system development and function, including neuronal migration, synaptogenesis, induction of the blood-brain-barrier, metabolic support of ...
openaire   +2 more sources

TGF-β1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factor (TGF)-β1, an important inflammatory cytokine, in vascular epithelium. The goal of this study was to determine if FGF-2 production by alveolar type II cells is modulated by TGF-β1 or FGF-1, which ...
Ines Pagan   +4 more
openaire   +3 more sources

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