Fibroblast growth factor 2 - Open Access .click

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Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Arthritis & Rheumatism, 2009
OBJECTIVE We have previously identified in articular cartilage an abundant pool of the heparin-binding growth factor, fibroblast growth factor 2 (FGF-2), which is bound to the pericellular matrix heparan sulfate proteoglycan, perlecan. This pool of FGF-2
S. Chia +6 more
semanticscholar +1 more source

Immunclocalization of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 and Receptor-2 in Rat Cranial Sutures

Plastic and Reconstructive Surgery, 1998
Craniosynostosis is a common disorder with an unknown etiology. Recent genetic mapping studies have demonstrated a strong linkage between several familial craniosynostotic syndromes and mutations in fibroblast growth factor receptor 1 (FGF-R1) and 2 (FGF-R2).
Michael T. Longaker +4 more
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Modifications of the fibroblast growth factor‐2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor‐2 protein

Journal of Cellular Biochemistry, 2007
AbstractProgress in FGF‐2 gene therapy has been hampered by the difficulty in achieving therapeutic levels of FGF‐2 secretion. This study tested whether the addition of BMP2/4 hybrid secretion signal to the FGF‐2 gene and mutation of cys‐70 and cys‐88 to serine and asparagine, respectively, would increase the stability and secretion of active FGF‐2 ...
Sonia Kapur +4 more
openaire +3 more sources

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