Results 31 to 40 of about 536,398 (346)

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*

Journal of Biological Chemistry, 2006
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the
H. Kurosu, Y. Ogawa, Masayoshi Miyoshi, Masaya Yamamoto, A. Nandi, K. Rosenblatt, M. Baum, S. Schiavi, M. Hu, O. Moe, M. Kuro-o   +10 more
semanticscholar   +1 more source

Fibroblast Growth Factor-23 (FGF-23) e Sindrome Cardiorenale

Giornale di Clinica Nefrologia e Dialisi, 2015
non disponibile (Cardionephrology)
Luca Di Lullo, Rodolfo Rivera, Antonio De Pascalis, Fulvio Floccari, Vincenzo Barbera, Claudio Ronco, Alberto Santoboni1   +6 more
doaj   +1 more source

Serum intact fibroblast growth factor 23 in healthy paediatric population

Open Medicine, 2021
It is believed that fibroblast growth factor 23 (FGF23) can become an early biomarker of chronic kidney disease progression. Data on FGF23 age dependency are inconsistent.
Stanczyk Malgorzata, Chrul Slawomir, Wyka Krystyna, Tkaczyk Marcin   +3 more
doaj   +1 more source

Fibroblast Growth Factor–23 and Cardiac Structure and Function [PDF]

, 2014
Background: Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease.
Agarwal, Isha, Ide, Noriko, Ix, Joachim H., Kestenbaum, Bryan, Lanske, Beate, Mukamal, Kenneth J., Schiller, Nelson B., Whooley, Mary A.   +7 more
core   +1 more source

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.

Kidney International, 2011
Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. FGF23 is thought to be an early biomarker of disordered phosphorus metabolism in the initial stages of chronic kidney disease
T. Isakova, P. Wahl, Gabriela Vargas, O. Gutiérrez, J. Scialla, Huiliang Xie, D. Appleby, L. Nessel, K. Bellovich, J. Chen, L. Hamm, C. Gadegbeku, Edward J. Horwitz, R. Townsend, C. Anderson, J. Lash, Chi-yuan Hsu, M. Leonard, M. Wolf   +18 more
semanticscholar   +1 more source

Fibroblast growth factor 23: fueling the fire [PDF]

Kidney International, 2016
In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines.
Hanudel, Mark, Jüppner, Harald, Salusky, Isidro B   +2 more
openaire   +4 more sources

MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23 [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in ...
Shouhua Zheng, Shuijun Zhang, Yan Song, Wenzhi Guo, Wenlong Zhai, Xinguang Qiu, Jianhua Li   +6 more
doaj   +1 more source

Iron and fibroblast growth factor 23 in X-linked hypophosphatemia [PDF]

, 2014
Background Excess fibroblast growth factor 23 (FGF23) causes hypophosphatemia in autosomal dominant hypophosphatemic rickets (ADHR) and X-linked hypophosphatemia (XLH). Iron status influences C-terminal FGF23 (incorporating fragments plus intact FGF23)
Econs, Michael J., Gray, Amie, Imel, Erik A., Padgett, Leah   +3 more
core   +1 more source

Effects of etelcalcetide on fibroblast growth factor 23 in patients with secondary hyperparathyroidism receiving hemodialysis [PDF]

, 2019
Background: Etelcalcetide is an intravenous calcimimetic approved for treatment of secondary hyperparathyroidism (sHPT) in patients receiving hemodialysis. Besides lowering parathyroid hormone (PTH), etelcalcetide also significantly reduces fibroblast
Block, Geoffrey A., Chertow, Glenn M., Cooper, Kerry, Fouqueray, Bruno, Moe, Sharon M., Oberbauer, Rainer, Sun, Yan, Tomlin, Holly, Vervloet, Marc, Wolf, Myles   +9 more
core   +1 more source

Multiple faces of fibroblast growth factor-23 [PDF]

Current Opinion in Nephrology and Hypertension, 2016
This review examines the role of fibroblast growth factor-23 (FGF-23) in mineral metabolism, innate immunity and adverse cardiovascular outcomes.FGF-23, produced by osteocytes in bone, activates FGFR/α-Klotho (α-Kl) complexes in the kidney. The resulting bone-kidney axis coordinates renal phosphate reabsorption with bone mineralization, and creates a ...
Xiaobin, Han, L Darryl, Quarles
openaire   +2 more sources