Results 1 to 10 of about 74,102 (246)

Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB [PDF]

Journal of Structural Biology: X
Fibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye, Martin Marek, Tereza Ghazalova, Jiri Damborsky, Petr Pachl, Jiri Brynda, Veronika Stepankova, Radka Chaloupkova   +7 more
doaj   +6 more sources

Down-Regulation of Fibroblast Growth Factor 2 (FGF2) Contributes to the Premature Senescence of Mouse Embryonic Fibroblast. [PDF]

Med Sci Monit, 2020
Background Freshly isolated mouse embryonic fibroblasts (MEFs) have great proliferation capacity but quickly enter senescent state after several rounds of cell cycle, a process called premature senescence.
Li J, Song S, Li X, Zhu J, Li W, Du B, Guo Y, Xi X, Han R.   +8 more
europepmc   +5 more sources

A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2). [PDF]

Biomacromolecules, 2016
Fibroblast growth factor 2 (FGF2) is a protein involved in cellular functions in applications such as wound healing and tissue regeneration. Stabilization of this protein is important for its use as a therapeutic since the native protein is unstable ...
Paluck SJ, Nguyen TH, Lee JP, Maynard HD.   +3 more
europepmc   +4 more sources

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. [PDF]

J Biol Chem, 2017
Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is relevant to hepatic inflammation, fibrosis, and cancer because of its ...
Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N.   +12 more
europepmc   +6 more sources

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors. [PDF]

ACS Omega, 2017
Antibody–drug conjugates (ADCs) are a new class of anticancer therapeutics that combine the selectivity of targeted treatment, ensured by monoclonal antibodies, with the potency of the cytotoxic agent.
Krzyscik MA, Zakrzewska M, Sørensen V, Sokolowska-Wedzina A, Lobocki M, Swiderska KW, Krowarsch D, Wiedlocha A, Otlewski J.   +8 more
europepmc   +6 more sources

Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity

Sensors, 2009
Angiogenesis, the process of new blood vessel formation, is implicated in various physiological/pathological conditions, including embryonic development, inflammation and tumor growth.
Marco Presta, Laura E. Depero, Paolo Bergese, Daria Leali, Stefania Mitola, Antonella Bugatti, Marco Rusnati   +6 more
doaj   +5 more sources

Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells. [PDF]

Oncotarget, 2015
Human glioblastoma multiforme (GBM) is the most malignant tumor of the central nervous system (CNS). Fibroblast growth factor-2 (FGF2) belongs to the FGF superfamily and functions as a potential oncoprotein in GBM. FGF2 has low molecular weight (18K) and
Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, Zheng J, Jiao B.   +7 more
europepmc   +5 more sources

Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies. [PDF]

Oncotarget, 2016
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR) with varying affinities.
Akl MR, Nagpal P, Ayoub NM, Tai B, Prabhu SA, Capac CM, Gliksman M, Goy A, Suh KS.   +8 more
europepmc   +2 more sources

Novel Regulation of Fibroblast Growth Factor 2 (FGF2)-mediated Cell Growth by Polysialic Acid* [PDF]

Journal of Biological Chemistry, 2011
Background: Polysialic acid (polySia) binds neurological factors, BDNF and dopamine. Results: PolySia specifically binds FGF2 and inhibits the cell growth facilitated by signaling through a ternary complex of FGF2, FGFR, and heparan sulfate (HS ...
S. Ono, Masaya Hane, K. Kitajima, C. Sato   +3 more
semanticscholar   +3 more sources

Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination† [PDF]

Journal of Neuroscience Research, 2000
Fibroblast growth factor 2 (FGF2) is an excellent candidate to regulate remyelination based on its proposed actions in oligodendrocyte lineage cell development in conjunction with its involvement in CNS regeneration.
D. Messersmith, J. Murtie, T. Q. Le, E. Frost, R. Armstrong   +4 more
semanticscholar   +3 more sources