Results 131 to 140 of about 74,102 (246)
Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core +1 more source
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. ABSTRACT Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]
Peer reviewedPublisher ...
A Kubo +42 more
core +2 more sources
A personalizable platform featuring a multi‐zonal cardiac patch design at clinical scale enables precise customization of fiber architecture at micro‐ and macroscale via melt electrowriting. Distinct scaffold zones support cell alignment with mechanical force transfer and epicardial attachment.
Johannes Braig +31 more
wiley +1 more source
Background: Gestational diabetes mellitus (GDM) is associated with structural and functional alterations in various tissues including endothelial dysfunction. The aim of this study was to explore the effects of hyperglycemia on fibroblast growth factor 2
Jian Zhou +6 more
doaj +1 more source
Challenges and possible clinical applications of human embryonic stem cell research [PDF]
Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra +3 more
core +1 more source
FGF2 promotes Msx2 stimulated PC‐1 expression via Frs2/MAPK signaling [PDF]
PC‐1 is an enzymatic generator of pyrophosphate and a critical regulator of tissue mineralization. We previously showed that fibroblast growth factor‐2 (FGF2) specifically induces PC‐1 expression in calvarial pre‐osteoblasts and that this occurs via a ...
Hatch, Nan E. +4 more
core +1 more source
ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation rates ...
Tang Yuqing +5 more
wiley +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh +13 more
wiley +1 more source

