Results 141 to 150 of about 74,102 (246)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Fully Dedifferentiated Chondrocytes Expanded in Specific Mesenchymal Stem Cell Growth Medium with FGF2 Obtains Mesenchymal Stem Cell Phenotype In Vitro but Retains Chondrocyte Phenotype In Vivo

Cell Transplantation, 2017
Given recent progress in regenerative medicine, we need a means to expand chondrocytes in quantity without losing their regenerative capability. Although many reports have shown that growth factor supplementation can have beneficial effects, the use of ...
Jungsun Lee, Jin-Yeon Lee, Byung-Chul Chae, Jeongho Jang, EunAh Lee, Youngsook Son   +5 more
doaj   +1 more source

Engineering Cadherin‐Guided MSC Aggregates to Empower Synergistic Neurovascular Repair After Stroke

Aggregate, Volume 7, Issue 3, March 2026.
A cadherin‐directed bioengineering strategy transforms mesenchymal stem cell aggregation from passive clustering into active functional programming. The resulting cadherin‐guided aggregates exhibit reinforced microstructure, stress resistance, and an enhanced pro‐regenerative secretome, enabling coordinated neurovascular repair in ischemic stroke.
Guoqiang Chen, Lin Wang, Yameng Chen, Jiaxu Cao, Xiuyan Jiang, Zheng Qin, Yan Zhang, Tao Yan, Jun Yang   +8 more
wiley   +1 more source

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Bohlen und Halbach, Oliver von, Dono, Rosanna, Kiprianova, Irina, Krause, Sonja, Schindowski, Katharina, Schwaninger, Markus, Unsicker, Klaus   +6 more
core  

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Combining EVs with biomaterials enables sustained, targeted delivery and overcomes traditional limitations. EVs show great promise in diagnosing and treating oral diseases, and could transform oral health management strategies. ABSTRACT Oral diseases impair oral function and are closely linked to various systemic conditions.
Zhe Zhao, Yiyu Zeng, Rui Liu, Xuemei Qiu
wiley   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

FGFR3 drives Aβ-induced tau uptake

Experimental and Molecular Medicine
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD). However, the underlying mechanisms through which Aβ contributes to tau uptake and propagation remain poorly ...
Dong Kyu Kim, Kyujin Suh, Junho Park, Sang-Eun Lee, Jihui Han, Sunghoe Chang, Youngsoo Kim, Inhee Mook-Jung   +7 more
doaj   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

The Prebiotic and Techno‐Functional Potential of Microbial Exopolysaccharides for Human Health and Food Systems

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 2, March 2026.
ABSTRACT Microbial exopolysaccharides (EPS) represent a diverse class of biopolymers holding considerable promise as functional food ingredients. This review analyzes the dual function of microbial EPS as a candidate for prebiotic agents and techno‐functional additives.
Md. Abdur Razzak, Hye Kim, Md. Ariful Haque, Min Ji Jang, Sehyeon Song, Anishka Talari, Lakshmi Devi Chittepu, Seockmo Ku   +7 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source