Results 11 to 20 of about 74,102 (246)

Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth. [PDF]

Growth Factors, 2020
FGF2 is a potent stimulator of vascular growth; however, even with a deficiency of FGF2 (Fgf2-/-), developmental vessel growth or ischaemia-induced revascularization still transpires. It remains to be elucidated as to what function, if any, FGF2 has during ischaemic injury. Wildtype (WT) or Fgf2-/- mice were subjected to hindlimb ischaemia for up to 42
Adeyemo A, Johnson C, Stiene A, LaSance K, Qi Z, Lemen L, Schultz JEJ.   +6 more
europepmc   +4 more sources

Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation

FEBS Open Bio, 2023
Fibroblast growth factor (FGF) signaling plays a crucial role in lung development and repair. Fibroblast growth factor 2 (FGF2) can inhibit fibrotic gene expression and suppress the differentiation of pulmonary fibroblasts (PFs) into myofibroblasts in ...
Xiangqin Tian, Yangyang Jia, Yonglong Guo, Hongyin Liu, Xinhua Cai, Yong Li, Zhuangzhuang Tian, Changye Sun   +7 more
doaj   +2 more sources

Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology. [PDF]

Reproduction, 2018
Fibroblast growth factor 2 (FGF2) and its receptors (FGFRs) have been described in several tissues, where they regulate cellular proliferation, differentiation, motility and apoptosis.
Lucia Saucedo, C. Sobarzo, N. G. Brukman, H. Guidobaldi, L. Lustig, L. Giojalas, M. Buffone, M. Vazquez-Levin, C. Marín-Briggiler   +8 more
semanticscholar   +4 more sources

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1). [PDF]

Mol Pharm, 2020
In spite of significant progress in the field of targeted anticancer therapy, the FDA has approved only five ADC-based drugs. Hence the search for new targeted anticancer agents is an unfulfilled necessity. Here, we present novel types of protein-drug conjugates (PDCs) that exhibit superior anticancer activities.
Krzyscik MA, Zakrzewska M, Otlewski J.
europepmc   +4 more sources

HoxA10 Protein Regulates Transcription of Gene Encoding Fibroblast Growth Factor 2 (FGF2) in Myeloid Cells* [PDF]

Journal of Biological Chemistry, 2012
Background: HoxA10 is a homeodomain transcription factor that regulates myeloid progenitor cell expansion and contributes to myeloid leukemogenesis.
C. Shah, L. Bei, Hao Wang, L. Platanias, E. Eklund   +4 more
semanticscholar   +3 more sources

The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2)

Angiogenesis, 2018
Thrombospondin (TSP)-1 and TSP-2 share similar structures and functions, including a remarkable antiangiogenic activity. We have previously demonstrated that a mechanism of the antiangiogenic activity of TSP-1 is the interaction of its type III repeats domain with fibroblast growth factor-2 (FGF2), affecting the growth factor bioavailability and ...
M. Rusnati, Patrizia Borsotti, E. Moroni, C. Foglieni, P. Chiodelli, L. Carminati, D. Pinessi, D. Annis, Giulia Paiardi, A. Bugatti, A. Gori, R. Longhi, D. Belotti, D. Mosher, G. Colombo, G. Taraboletti   +15 more
semanticscholar   +6 more sources

Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation

Scientific Reports, 2022
Fibroblast growth factor-2 (FGF2) has multiple roles in cutaneous wound healing but its natural low stability prevents the development of its use in skin repair therapies.
Isabelle Petit, Ayelet Levy, Soline Estrach, Chloé C. Féral, Andrea Gonçalves Trentin, Florent Dingli, Damarys Loew, Jieqiong Qu, Huiqing Zhou, Clotilde Théry, Céline Prunier, Daniel Aberdam, Olivier Ferrigno   +12 more
doaj   +2 more sources

Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals [PDF]

Proceedings of the National Academy of Sciences, 2011
Individuals with mood disorders exhibit alterations in the fibroblast growth factor system, including reduced hippocampal fibroblast growth factor-2 (FGF2). It is difficult, however, to pinpoint whether these alterations are a cause or consequence of the disorder.
Cortney A. Turner, S. Clinton, Robert C. Thompson, S. Watson, H. Akil   +4 more
semanticscholar   +3 more sources

Fibroblasts are the most suitable cell source for regenerative medicine due to their high intracellular fibroblast growth factor 2 content

Biochemistry and Biophysics Reports, 2023
In our previous study, we found that dry-preserved multilayered fibroblast cell sheets promoted angiogenesis and wound healing in a mouse ulcer model by releasing high levels of intracellular fibroblast growth factor 2 (FGF2), hepatocyte growth factor ...
Masashi Yanagihara, Yutaro Matsuno, Koji Ueno, Hiroshi Kurazumi, Ryo Suzuki, Toshiki Tanaka, Kimikazu Hamano   +6 more
doaj   +2 more sources

Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro [PDF]

Journal of Bone and Mineral Research, 2013
Abstract Fibroblast growth factor 23 (FGF23) is responsible for phosphate wasting and the phenotypic changes observed in human diseases such as X-linked hypophosphatemia (XLH). Targeted overexpression of nuclear high–molecular weight fibroblast growth factor 2 isoforms (HMW isoforms) in osteoblasts resulted in a transgenic mouse with ...
Liping Xiao, Alycia Esliger, M. Hurley
semanticscholar   +3 more sources