Results 41 to 50 of about 74,102 (246)

Priming with a Combination of FGF2 and HGF Restores the Impaired Osteogenic Differentiation of Adipose-Derived Stem Cells

Cells, 2022
Classical aging-associated diseases include osteoporosis, diabetes, hypertension, and arthritis. Osteoporosis causes the bone to become brittle, increasing fracture risk.
Jeong Seop Park, Doyoung Kim, Hyun Sook Hong   +2 more
doaj   +1 more source

Fibroblast Growth Factor-2 Levels are Elevated in The Serum of Patients with Multiple Sclerosis [PDF]

Iranian Journal of Immunology, 2022
Background: Various factors contribute to the pathogenesis of Multiple Sclerosis (MS), one of which is Fibroblast Growth Factor 2 (FGF2). The function of FGF2 is pleiotropic.
Maryam Jari, Javad Sadeghi allah abadi, Davood Fathi, Marzieh Attar, Zahra Maleki, Majid Shahbazi   +5 more
doaj   +1 more source

Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model

Iranian Journal of Allergy, Asthma and Immunology, 2020
Impaired lung epithelial cell regeneration following injury may contribute to the development of pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a critical event in embryonic development, wound healing following injury, and even cancer ...
Lamis M.F. El-Baz, Nahla M. Shoukry, Hani S. Hafez, Robert D. Guzy, Mohamed Labib Salem   +4 more
doaj   +1 more source

FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Frontiers in Cell and Developmental Biology, 2020
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD ...
Yuanyang Tan, Yongkang Qiao, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang, Yan Yan, Yan Yan   +9 more
doaj   +1 more source

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. [PDF]

, 2017
We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed
Hamada, Yoshinosuke, Hatori, Nobuaki, Kawaguchi, Naomasa, Lam, Kit S, Matsuura, Nariaki, Mori, Seiji, Shih, Tsung-Chieh, Takada, Yoko K, Takada, Yoshikazu, Wu, Chun-Yi, Yamamoto, Hirofumi   +10 more
core   +2 more sources

Retinoic acid and fibroblast growth factor-2 play a key role on modulation of sex hormones and apoptosis in a mouse model of polycystic ovary syndrome induced by estradiol valerate

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: The main goal of the present study is to investigate the effects of retinoic acid and fibroblast growth factor-2 on serum levels of FSH and LH, histology, and apoptosis in the mouse model of Poly Cystic Ovary Syndrome (PCOS).
Ardeshir Moayeri, Ayoob Rostamzadeh, Amir Raoofi, Mohammad Jafar Rezaie, Zahra Abasian, Reza Ahmadi   +5 more
doaj   +1 more source

Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System

Frontiers in Molecular Neuroscience, 2021
The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents
Minjin Jeong, Minjin Jeong, Katarina Bojkovic, Varun Sagi, Varun Sagi, Konstantina M. Stankovic, Konstantina M. Stankovic   +6 more
doaj   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

Journal of Translational Medicine, 2011
Background Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with
Smeland Eivind, Sorbye Sveinung W, Valkov Andrej, Kilvaer Thomas K, Bremnes Roy M, Busund Lill-Tove, Donnem Tom   +6 more
doaj   +1 more source

Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion*

Journal of Biological Chemistry, 2012
Background: PI(4,5)P2- and tyrosine phosphorylation-dependent unconventional secretion of FGF2 is mediated by direct translocation across the plasma membrane.
Julia P Steringer, Stephanie Bleicken, Helena Andreas, Sonja Zacherl, Mareike Laußmann, K. Temmerman, F. Contreras, T. Bharat, J. Lechner, H. Müller, John A. G. Briggs, A. García-Sáez, W. Nickel   +12 more
semanticscholar   +1 more source