Results 51 to 60 of about 74,102 (246)

The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]

, 2019
Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca, Nanni, Monica, Persechino, Flavia, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway. [PDF]

PLoS ONE, 2013
We recently reported that paracrine Fibroblast Growth Factor 2 (FGF2) triggers senescence in Ras-driven Y1 and 3T3(Ras) mouse malignant cell lines. Here, we show that although FGF2 activates mitogenic pathways in these Ras-dependent malignant cells, it ...
Jacqueline Salotti, Matheus H Dias, Marianna M Koga, Hugo A Armelin   +3 more
doaj   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

Neurobiology of Disease, 2005
Repair of myelin damage in the adult CNS requires oligodendrocyte progenitor (OP) proliferation and subsequent differentiation into remyelinating oligodendrocytes.
Joshua C. Murtie, Yong-Xing Zhou, Tuan Q. Le, Adam C. Vana, Regina C. Armstrong   +4 more
doaj   +1 more source

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [PDF]

, 2013
Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by the fact that eEF2 is sensitive to
Argüelles Castilla, Sandro, Ayala Gómez, Antonio, Camandola, Simonetta, Cutler, Roy G.   +3 more
core   +1 more source

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Dimerization capacities of FGF2 purified with or without heparin-affinity chromatography. [PDF]

PLoS ONE, 2014
Fibroblast growth factor-2 (FGF2) is a pleiotropic growth factor exhibiting a variety of biological activities. In this article, we studied the capacity of FGF2 purified with or without heparin affinity chromatography to self-associate. Analyzing the NMR
Natalia Platonova, Géraldine Miquel, Liang-Yuan Chiu, Said Taouji, Elisabetta Moroni, Giorgio Colombo, Eric Chevet, Shih-Che Sue, Andreas Bikfalvi   +8 more
doaj   +1 more source

The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors. [PDF]

, 2015
The FDA-approved anti-DNA virus agent cidofovir (CDV) is being evaluated in phase II/III clinical trials for the treatment of human papillomavirus (HPV)-associated tumors.
Gijsbers S., Liekens S., Noppen S., Presta M., Ronca R., Sienaert R., Tobia C.   +6 more
core   +1 more source