Results 71 to 80 of about 74,102 (246)

Prolyl Isomerase Pin1-mediated Conformational Change and Subnuclear Focal Accumulation of Runx2 Are Crucial for Fibroblast Growth Factor 2 (FGF2)-induced Osteoblast Differentiation*

Journal of Biological Chemistry, 2014
Background: Genetic interaction between Runx2 and Pin1 is critical for embryonic bone formation. Results: Pin1 is a critical modifying enzyme promoting both subnuclear accumulation and protein acetylation of Runx2. Conclusion: Pin1 determines the fate of
Won-joon Yoon, Young‐Dan Cho, Woo-Jin Kim, H. Bae, R. Islam, K. Woo, J. Baek, S. Bae, H. Ryoo   +8 more
semanticscholar   +1 more source

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]

, 2020
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó, Guimond, Scott E., Hofmann, Johanna, Manz, Christian, Miller, Rebecca L., Pagel, Kevin, Schwörer, Ralf, Tyler, Peter C., Xu, Yongmei [u.v.m.], Zubkova, Olga V.   +9 more
core   +1 more source

Direct Cardiac Reprogramming: Progress and Promise. [PDF]

, 2018
The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure.
Ardehali, Reza, Engel, James L
core   +7 more sources

Modeling human pancreatic beta cell dedifferentiation

Molecular Metabolism, 2018
Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann   +14 more
doaj   +1 more source

FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]

, 2007
After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C., Fairless, R., Frame, M.C., Montague, P., Riddell, J.S., Santos-Silva, A., Smith, G.M., Toft, A.   +7 more
core   +3 more sources

FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells

Military Medical Research, 2022
Background Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2 (FGF2) has been reported to be an inflammatory regulator; however, its role in ...
Yuan-Yang Tan, Hui-Qin Zhou, Yu-Jing Lin, Liu-Tong Yi, Zhuang-Gui Chen, Qing-Dong Cao, Yan-Rong Guo, Zhao-Ni Wang, Shou-Deng Chen, Yang Li, De-Yun Wang, Yong-Kang Qiao, Yan Yan   +12 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation. [PDF]

PLoS ONE, 2012
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a ...
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang   +6 more
doaj   +1 more source

High molecular weight Fibroblast Growth Factor 2 (FGF2) requires an active Fibroblast Growth Factor Receptor 1 (FGFR1) to depress post‐ischemic cardiac function

The FASEB Journal, 2009
Fibroblast growth factor 2 (FGF2) is a family of isoforms with potential both as therapeutic molecules, as well as endogenous targets for pharmacological modulation in cardiac ischemia. Our laboratory has previously demonstrated that the secreted low moledular weight (LMW) FGF2 isoform protects the heart ...
Janet R. Bodmer, Edward Wright, Gilbert Newman, Jo El J. Schultz   +3 more
openaire   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source