Results 281 to 290 of about 529,025 (348)

The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer. [PDF]

Cell Oncol (Dordr)
Di Giorgio C, Bellini R, Lupia A, Massa C, Urbani G, Bordoni M, Marchianò S, Rosselli R, De Gregorio R, Rapacciuolo P, Sepe V, Morretta E, Monti MC, Moraca F, Cari L, Ullah KRS, Natalizi N, Graziosi L, Distrutti E, Biagioli M, Catalanotti B, Donini A, Zampella A, Fiorucci S.   +23 more
europepmc   +1 more source

Evaluation of Fibroblast Growth Factor Receptor 3 (FGFR3) and Tumor Protein P53 (TP53) as Independent Prognostic Biomarkers in High-Grade Non-muscle Invasive Bladder Cancer. [PDF]

Cureus
Kumar A, Singh VK, Singh V, Singh MK, Shrivastava A, Sahu DK.   +5 more
europepmc   +1 more source

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

Science, 1997
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast growth factor receptor 1 (FGFR1) and showed differential ...
M. Mohammadi, G. Mcmahon, Li Sun, C. Tang, P. Hirth, Brian K. Yeh, S. Hubbard, J. Schlessinger   +7 more
semanticscholar   +1 more source

Fibroblast growth factors and their receptors

Biochemistry and Cell Biology, 1997
Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably.
John A. Smith, Anne R Kinsella, Zoya Galzie   +2 more
openaire   +3 more sources

Receptors for fibroblast growth factors

Immunology & Cell Biology, 1995
SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
John T Gallagher, Jacqueline C Coutts
openaire   +3 more sources

Fibroblast Growth Factor Receptor Inhibitors

Current Pharmaceutical Design, 2012
Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Raveendra Dayam, Suneel Kumar B.V.S, Lakshmi Narasu, Rambabu Gundla, Sarma J.A.R.P   +4 more
openaire   +2 more sources

Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs

Recent Patents on Cardiovascular Drug Discovery, 2006
Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that ...
Gregory J Chen, Reza Forough
openaire   +3 more sources

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors.

Journal of Clinical Oncology, 2015
PURPOSE JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. This first-in-human study evaluates the safety, pharmacokinetics, and pharmacodynamics and defines the recommended phase II dose (RP2D)
J. Tabernero, R. Bahleda, R. Dienstmann, J. Infante, A. Mita, A. Italiano, E. Calvo, V. Moreno, B. Adamo, A. Gazzah, B. Zhong, S. Platero, J. Smit, K. Stuyckens, M. Chatterjee‐Kishore, J. Rodón, V. Peddareddigari, F. Luo, J. Soria   +18 more
semanticscholar   +1 more source

Diverse receptors for fibroblast growth factors

Progress in Growth Factor Research, 1992
The development and maintenance of multicellular organisms requires a complex interplay between cells in different tissues. Many of the factors mediating cell-cell communication are polypeptides, which were originally identified because of their ability to stimulate cell growth.
Jaana Korhonen, Elina Armstrong, Kari Alitalo, Satu Vainikka, Juha Partanen   +4 more
openaire   +2 more sources