Results 291 to 300 of about 529,025 (348)
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Journal of Medicinal Chemistry, 2018
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19 (FGF19) signaling through fibroblast growth factor receptor 4 (FGFR4) has been identified as an ...
Xiaoyun Lu +4 more
semanticscholar +1 more source
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19 (FGF19) signaling through fibroblast growth factor receptor 4 (FGFR4) has been identified as an ...
Xiaoyun Lu +4 more
semanticscholar +1 more source
Promiscuity of fibroblast growth factor receptors
BioEssays, 1996AbstractFibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in ...
Frank S. Walsh +2 more
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Muscle and Nerve, 2019
Causes of small‐fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor‐3 (FGFR‐3), and immunoglobulin M (IgM) vs trisulfated
T. Levine +6 more
semanticscholar +1 more source
Causes of small‐fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor‐3 (FGFR‐3), and immunoglobulin M (IgM) vs trisulfated
T. Levine +6 more
semanticscholar +1 more source
Fibroblast growth factors and their receptors in cancer
Biochemical Journal, 2011FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer.
Jørgen Wesche +2 more
openaire +2 more sources
Development, 2000
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions.
L. Moerlooze +5 more
semanticscholar +1 more source
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions.
L. Moerlooze +5 more
semanticscholar +1 more source
Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling
Thrombosis and Haemostasis, 1999A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well described as mediators of a variety of diverse biological responses, such as mesoderm induction ...
Thomas Maciag, Robert Friesel
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Journal of Neurochemistry, 2007
AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
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AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
openaire +3 more sources
Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium
Brain Research, 2001Basic fibroblast growth factor (FGF2) stimulates proliferation of the globose basal cells, the neuronal precursor in the olfactory epithelium. The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor receptors in the adult olfactory epithelium.
Hsu, P +5 more
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Fibroblast Growth Factor Receptors
1997Fibroblast growth factor (FGF) was discovered in the 1970s as an activity that stimulates the proliferation of 3T3 cells (1). Currently, FGFs comprise a family of nine structurally related proteins (FGF-1 to -9) (reviewed in 2–6). FGFs are expressed in specific spatial and temporal patterns and are involved in developmental processes, angiogenesis ...
Gabriel Waksman, David M. Ornitz
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Isoforms of Receptors of Fibroblast Growth Factors
Journal of Cellular Physiology, 2014The breadth and scope of Fibroblast Growth Factor signaling is immense, with documentation of its role in almost every organism and system studied so far. FGF ligands signal through a family of four distinct tyrosine kinase receptors, the FGF receptors (FGFRs).
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