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Diverse receptors for fibroblast growth factors
Progress in Growth Factor Research, 1992The development and maintenance of multicellular organisms requires a complex interplay between cells in different tissues. Many of the factors mediating cell-cell communication are polypeptides, which were originally identified because of their ability to stimulate cell growth.
J, Partanen +4 more
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Fibroblast growth factors and their receptors
Biochemistry and Cell Biology, 1997Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably.
Z, Galzie, A R, Kinsella, J A, Smith
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Fibroblast Growth Factor Receptors
1997Fibroblast growth factor (FGF) was discovered in the 1970s as an activity that stimulates the proliferation of 3T3 cells (1). Currently, FGFs comprise a family of nine structurally related proteins (FGF-1 to -9) (reviewed in 2–6). FGFs are expressed in specific spatial and temporal patterns and are involved in developmental processes, angiogenesis ...
David M. Ornitz, Gabriel Waksman
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Journal of Neurochemistry, 2007
AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
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AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
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Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium
Brain Research, 2001Basic fibroblast growth factor (FGF2) stimulates proliferation of the globose basal cells, the neuronal precursor in the olfactory epithelium. The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor receptors in the adult olfactory epithelium.
Hsu, P +5 more
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Fibroblast Growth Factor 23 and Its Receptors
Therapeutic Apheresis and Dialysis, 2005Abstract: Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately ...
Xijie, Yu, Kenneth E, White
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Cellular signaling by fibroblast growth factor receptors
Cytokine & Growth Factor Reviews, 2005The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4.
V P, Eswarakumar +2 more
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Anticancer molecules targeting fibroblast growth factor receptors
Trends in Pharmacological Sciences, 2012The fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor tyrosine kinases: FGFR1-4. Upon ligand binding, FGFRs activate an array of downstream signaling pathways, such as the mitogen activated protein kinase (MAPK) and the phosphoinositide-3-kinase (PI3K)/Akt pathways.
Guang, Liang +4 more
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Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich +3 more
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Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich +3 more
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Isoforms of Receptors of Fibroblast Growth Factors
Journal of Cellular Physiology, 2014The breadth and scope of Fibroblast Growth Factor signaling is immense, with documentation of its role in almost every organism and system studied so far. FGF ligands signal through a family of four distinct tyrosine kinase receptors, the FGF receptors (FGFRs).
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