Results 331 to 340 of about 665,368 (391)

Fibroblast Growth Factor Receptor Inhibitors

Current Pharmaceutical Design, 2012
Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Raveendra Dayam, Suneel Kumar B.V.S, Lakshmi Narasu, Rambabu Gundla, Sarma J.A.R.P   +4 more
openaire   +2 more sources

Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs

Recent Patents on Cardiovascular Drug Discovery, 2006
Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that ...
Gregory J Chen, Reza Forough
openaire   +3 more sources

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors.

Journal of Clinical Oncology, 2015
PURPOSE JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. This first-in-human study evaluates the safety, pharmacokinetics, and pharmacodynamics and defines the recommended phase II dose (RP2D)
J. Tabernero, R. Bahleda, R. Dienstmann, J. Infante, A. Mita, A. Italiano, E. Calvo, V. Moreno, B. Adamo, A. Gazzah, B. Zhong, S. Platero, J. Smit, K. Stuyckens, M. Chatterjee‐Kishore, J. Rodón, V. Peddareddigari, F. Luo, J. Soria   +18 more
semanticscholar   +1 more source

Diverse receptors for fibroblast growth factors

Progress in Growth Factor Research, 1992
The development and maintenance of multicellular organisms requires a complex interplay between cells in different tissues. Many of the factors mediating cell-cell communication are polypeptides, which were originally identified because of their ability to stimulate cell growth.
Jaana Korhonen, Elina Armstrong, Kari Alitalo, Satu Vainikka, Juha Partanen   +4 more
openaire   +2 more sources

Cryptogenic small‐fiber neuropathies: Serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor‐3

Muscle and Nerve, 2019
Causes of small‐fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor‐3 (FGFR‐3), and immunoglobulin M (IgM) vs trisulfated
T. Levine, Jafar Kafaie, L. Zeidman, D. Saperstein, Reyanna Massaquoi, Ruth Bland, A. Pestronk   +6 more
semanticscholar   +1 more source

Promiscuity of fibroblast growth factor receptors

BioEssays, 1996
AbstractFibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in ...
Frank S. Walsh, Paula J. Green, Patrick Doherty   +2 more
openaire   +3 more sources

Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects.

Journal of Medicinal Chemistry, 2018
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19 (FGF19) signaling through fibroblast growth factor receptor 4 (FGFR4) has been identified as an ...
Xiaoyun Lu, Hao Chen, A. Patterson, J. Smaill, Ke Ding   +4 more
semanticscholar   +1 more source

Fibroblast growth factors and their receptors in cancer

Biochemical Journal, 2011
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer.
Jørgen Wesche, Ellen Margrethe Haugsten, Kaisa Haglund   +2 more
openaire   +2 more sources

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

Development, 2000
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions.
L. Moerlooze, B. Spencer‐Dene, J. Revest, M. Hajihosseini, I. Rosewell, C. Dickson   +5 more
semanticscholar   +1 more source

Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling

Thrombosis and Haemostasis, 1999
A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well described as mediators of a variety of diverse biological responses, such as mesoderm induction ...
Thomas Maciag, Robert Friesel
openaire   +3 more sources