Results 61 to 70 of about 221,633 (255)

Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus [PDF]

Biological Psychiatry, 2012
Fibroblast growth factor (FGF) signaling controls self-renewal of neural stem cells during embryonic telencephalic development. FGF receptor 2 (FGFR2) has a significant role in the production of cortical neurons during embryogenesis, but its role in the hippocampus during development and in adulthood has not been described.Here we dissociate the role ...
Hanna E, Stevens, Ginger Y, Jiang, Michael L, Schwartz, Flora M, Vaccarino   +3 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Association of FGF Receptor-2rs2981578 SNP with breast cancer in women at the University of Gondar Comprehensive Specialized Hospital, Ethiopia.

PLoS ONE
IntroductionFibroblast Growth Factor Receptor-2 single nucleotide polymorphisms are implicated in breast cancer development. However, there are inconsistencies and contradictions in the reports.
Mihiret Bogale, Tiget Ayelgn Mengstie, Ephrem Tadesse, Tadesse Asmamaw Dejenie, Banchamlak Teferi, Melkamu Siferih, Mulualem Nibret Takle, Tseganesh Asefa, Gashaw Dessie, Winta Tesfaye, Endeshaw Asaye Kindie, Hiwot Tezera Endale, Kibur Hunie Tesfa, Birhanu Ayelign, Tewodros Shibabaw   +14 more
doaj   +1 more source

Moxibustion inhibits growth of tumor by down-regulating expression of FGFR1 and VEGFR2 in mice with sarcoma

针刺研究, 2021
Objective To observe the effect of moxibustion on the growth of tumor and expression of fibroblast growth factor receptor 1(FGFR1) and vascular endothelial cell growth factor receptor 2(VEGFR2) in mice with sarcoma, so as to explore its mechanisms ...
LI Li-jun, LUO Min-xiang, HE Li-jiao, ZHAO Chang-lin   +3 more
doaj  

Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model

Journal of Bone Oncology, 2019
Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance in bone formation and resorption.
Tiina E. Kähkönen, Johanna M. Tuomela, Tove J. Grönroos, Jussi M. Halleen, Kaisa K. Ivaska, Pirkko L. Härkönen   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

MicroRNA-Regulated Rickettsial Invasion into Host Endothelium via Fibroblast Growth Factor 2 and Its Receptor FGFR1

Cells, 2018
Microvascular endothelial cells (ECs) represent the primary target cells during human rickettsioses and respond to infection via the activation of immediate⁻early signaling cascades and the resultant induction of gene expression. As small noncoding
Abha Sahni, Hema P. Narra, Jignesh Patel, Sanjeev K. Sahni   +3 more
doaj   +1 more source

The neural cell adhesion molecule binds to fibroblast growth factor receptor 2 [PDF]

FEBS Letters, 2006
The neural cell adhesion molecule (NCAM) can bind to and activate fibroblast growth factor receptor 1 (FGFR1). However, there are four major FGFR isoforms (FGFR1–FGFR4), and it is not known whether NCAM also interacts directly with the other three FGFR isoforms.
Christensen, Claus, Lauridsen, Jes B, Berezin, Vladimir, Bock, Elisabeth, Kiselyov, Vladislav V   +4 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

New derivatives based on zerumbone scaffold as anticancer inhibitors: Synthesis, in vitro anticancer evaluation, docking, and MD simulation studies

Journal of Chemical Research
A three-step procedure was applied to synthesize seven novel zerumbone ethers 7a–g with N -(4-hydroxybenzyl) benzamide, N -(4-hydroxybenzyl) substituted benzamide, and N -(4-hydroxybenzyl) cinnamamide moieties, including simultaneous O - and N ...
Ngoc Hung Truong, Minh Ha Le, Hanh Trang Luu, Tien Chinh Vu, Van Chung Pham, Van Chinh Luu   +5 more
doaj   +1 more source