Results 21 to 30 of about 356,203 (328)

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia [PDF]

Proceedings of the National Academy of Sciences, 2003
Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes.
Jay Y. Cho, Changsheng Guo, Monica Torello, Gregory P. Lunstrum, Tomoko Iwata, Chu‐Xia Deng, William A. Horton   +6 more
openalex   +3 more sources

A novel S269C mutation in fibroblast growth factor receptor 3 in a Japanese child with hypochondroplasia. [PDF]

Hum Genome Var, 2018
Takahashi I, Kondo D, Oyama C, Yano T, Tamura H, Noguchi A, Takahashi T.   +6 more
europepmc   +3 more sources

Longitudinal Imaging of the Skull Base Synchondroses Demonstrate Prevention of a Premature Ossification After Recifercept Treatment in Mouse Model of Achondroplasia

JBMR Plus, 2022
Achondroplasia is the most common form of short‐limb dwarfism. In this disorder, endochondral ossification is impaired due to gain‐of‐function mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene.
Guylene Rignol, Stephanie Garcia, Florence Authier, Kaamula Smith, Lionel Tosello, Raphael Marsault, Pierre Dellugat, Diogo Goncalves, Marlene Brouillard, Jeffrey Stavenhagen, Luca Santarelli, Christian Czech, Elvire Gouze   +12 more
doaj   +1 more source

Fibroblast growth factor receptor 3 deficiency does not impair the osteoanabolic action of parathyroid hormone on mice [PDF]

Journal of Orthopaedic Translation, 2016
Yangli Xie, Wei Xu, Siru Zhou, Junlan Huang, Xiaolan Du, Lin Chen   +5 more
doaj   +2 more sources

Durable response from fibroblast growth factor receptor inhibition in intrahepatic cholangiocarcinoma terminated by metachronous acute myeloid leukemia: a case report

Journal of Medical Case Reports, 2023
Introduction Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a ...
Andreas Edwin Juarso, Stefanie Entz, Florian Weissinger   +2 more
doaj   +1 more source

Cysteine-rich Fibroblast Growth Factor Receptor Alters Secretion and Intracellular Routing of Fibroblast Growth Factor 3 [PDF]

Journal of Biological Chemistry, 2000
Expression of the cysteine-rich fibroblast growth factor (FGF) receptor (CFR) in COS-1 cells strongly inhibits the secretion of co-expressed FGF3. By using a column retention assay and affinity chromatography, we demonstrate that at physiological salt concentrations FGF3 binds with strong affinity to CFR in vivo and in vitro.
R, Köhl, M, Antoine, B B, Olwin, C, Dickson, P, Kiefer   +4 more
openaire   +2 more sources

VEGFR1-tyrosine kinase signaling in pulmonary fibrosis

Inflammation and Regeneration, 2021
Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono, Yoshiya Ito   +4 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 3 Gene: Regulation by Serum Response Factor [PDF]

Molecular Endocrinology, 2004
We have previously identified a cis-acting sequence in the proximal promoter of the fibroblast growth factor receptor 3 (FGFR3) gene that strongly activates transcription in chondrocytic cells. Here we report that the transcriptional activity of this sequence (FRE3) requires serum response factor and its cognate recognition motif, serum response ...
Martina I, Reinhold, Donald G, McEwen, Michael C, Naski   +2 more
openaire   +2 more sources

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis [PDF]

, 2010
The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such
A Galli, A Kis, A Milano, AK Ghosh, AK Ghosh, AK Ghosh, AK Ghosh, Asish K. Ghosh, BC Willis, BM Psaty, C Beyer, C Dong, Carol Feghali-Bostwick, DA Culver, ED Rosen, ED Rosen, F Verrecchia, F Zheng, G Lakos, H Ha, HA Burgess, J Berger, J Varga, J Varga, JE Milam, Jennifer L. Sargent, JL Sargent, John Varga, Joy Sturtevant, JT Tan, Jun Wei, KA Longo, Kazuhiro Komura, KM Hong, L Fajas, L Yang, LS Higgins, M Dudas, M Kapoor, M Kapoor, M Lehrke, M Trojanowska, M Wu, Manu Jain, MF Simon, Michael L. Whitfield, Minghua Wu, OA Gressner, P Karnik, P Tontonoz, Qi-Quan Huang, R Fleischmajer, S Dennler, S Kim, S Sonnylal, S Zheng, SE Ross, SH Liu, SJ Chen, SZ Duan, T Kawai, T Miyahara, T Shiomi, TM McIntyre, V Zoete, W Yuan, X Li, X Liu, X Shi-wen, X Tan, Y Mori, Y Mori, Y Park, Y Shi, Y Wang, Z Yun   +75 more
core   +13 more sources

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Bone Reports, 2020
Achondroplasia (ACH) is the most common form of short-limbed skeletal dysplasia. Patients with ACH sometimes undergo lower limb lengthening to get functional and psychological achievements.
Shinya Kaneko, Masaki Matsushita, Kenichi Mishima, Yasuhiko Takegami, Shiro Imagama, Hiroshi Kitoh   +5 more
doaj   +1 more source